Mechanism of Action:
Osmotic diuretics work by increasing the osmolarity of the filtrate in the renal tubules. They are filtered by the glomerulus but not reabsorbed, leading to an osmotic gradient that draws water into the nephron. This results in increased urine output and decreased intracranial and intraocular pressure.
- Absorption: Not applicable as they are often administered intravenously.
- Distribution: Limited distribution; mainly stays in the vascular and extracellular space.
- Metabolism: No metabolism; excreted unchanged.
- Excretion: Primarily renal excretion.
- Mannitol: Most commonly used; administered intravenously.
- Isosorbide: Less commonly used; oral administration.
- Acute Kidney Injury: To improve renal blood flow and filtration.
- Cerebral Edema: To reduce intracranial pressure.
- Glaucoma: To reduce intraocular pressure.
- Drug Overdose: To increase the excretion of certain substances.
- Dehydration: Due to increased urine output.
- Electrolyte Imbalance: Such as hyponatremia or hypernatremia.
- Pulmonary Edema: If used inappropriately in heart failure patients.
- Diuretics: Increased risk of dehydration and electrolyte imbalance.
- Antihypertensives: Increased risk of hypotension.
- Anuria (absence of urine production).
- Severe dehydration.
- Congestive heart failure (risk of pulmonary edema).
Disclaimer: This article is for informational purposes only and should not be taken as medical advice. Always consult with a healthcare professional before making any decisions related to medication or treatment.