The Comprehensive Guide to Anticancer Drugs: What You Need to Know

Introduction to Anticancer Drugs: Anticancer drugs are medications that inhibit the development and spread of cancerous cells. They achieve this by interfering with the DNA and RNA that cause cell division. Since cancer cells divide more rapidly than normal cells, they are more susceptible to these drugs. Classification of Anticancer Drugs: 1. Alkylating Agents: 2. Antimetabolites: 3. Natural Products: 4.

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Pharmacotherapy of Epilepsy

Introduction Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects millions of individuals worldwide (Katzung, 2020). While the underlying pathophysiology varies, epilepsy generally arises from aberrant, hypersynchronous neuronal discharges in the brain. Such episodes can manifest differently, ranging from brief lapses in awareness to severe convulsions. Pharmacotherapy remains the primary approach to controlling or reducing seizure occurrences, although surgical interventions or

By Pharmacology Mentor

Pharmacodynamic Principles: A Dive into Receptors and Binding Sites

Introduction Pharmacodynamics is the study of how drugs interact with biological systems, specifically focusing on the effects of drugs on the body. One of the most critical aspects of pharmacodynamics is the role of receptors and binding sites in mediating drug actions. This article aims to shed light on these complex interactions, explaining how drugs can act as agonists or

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Pharmacology of Anti-Androgens

I. Introduction and Historical Context Anti-androgens are a pharmacologically diverse class of agents

By Pharmacology Mentor

Sildenafil: Its Use as a PDE5 Inhibitor for Erectile Dysfunction

Phosphodiesterase type 5 (PDE5) inhibitors are first‑line oral agents for erectile dysfunction

By Pharmacology Mentor

Histamine and Antihistamines

Introduction Histamine stands as a fundamental mediator in allergic reactions, inflammatory processes,

By Pharmacology Mentor

Pharmacology of Antihypertensive agents

Antihypertensive agents form a diverse class of drugs that reduce elevated blood

By Pharmacology Mentor

Methanol Poisoning: Symptoms and Management

Methanol (methyl alcohol, wood alcohol) is a simple aliphatic alcohol with significant

By Pharmacology Mentor

Drugs used for the treatment of Glaucoma

This summary covers the major classes, mechanisms, indications, and clinical guidance for

By Pharmacology Mentor

Pharmacology of Pilocarpine

Introduction Pilocarpine is a naturally occurring alkaloid derived from the leaves of

By Pharmacology Mentor

Over-the-Counter (OTC) Drugs: A Comprehensive Overview

Main Takeaway: Over-the-counter (OTC) drugs are non-prescription medications available directly to consumers

By Pharmacology Mentor
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The Concept of P-Drugs in Rational Prescribing

Main Takeaway: A P-drug is a prescriber’s personal choice of first-line medicine for a specific indication, selected through a systematic and evidence-based process. Developing and maintaining a personal formulary of P-drugs streamlines decision-making, promotes rational therapeutics, and enhances patient safety. 1. Definition and Purpose of P-Drugs A P-drug (“personal drug”) is not merely the generic name of a medicine but encompasses: P-drugs serve as a clinician’s priority choices for given indications, reducing repetitive searches in daily practice and ensuring familiarity with each drug’s effects and side effects. 2. Relation to Essential Medicines and Guidelines 3. The Six-Step Process for Rational Prescribing The WHO Guide to Good Prescribing outlines a six-step model, with P-drug selection comprising Step 3: 4. Criteria for Selecting P-Drugs (The STEP Framework) When comparing drug options, apply the STEP criteria: Example: Selecting a P-Drug for Acute Amoebic Dysentery Among nitroimidazoles, tinidazole may be preferred over metronidazole due to similar efficacy and cost but greater suitability (shorter course, once- or twice-daily dosing). 5. Benefits of a P-Drug Formulary By systematically selecting and regularly reviewing P-drugs according to these principles, prescribers establish a robust foundation for safe, effective, and cost-conscious patient care.

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The Comprehensive Guide to Anticancer Drugs: What You Need to Know

Introduction to Anticancer Drugs: Anticancer drugs are medications that inhibit the development and spread of cancerous cells. They achieve this by interfering with the DNA and RNA that cause cell

By anonymous

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