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Pharmacology Mentor > Antimicrobial Chemotherapy – Antiviral and antifungal drugs

Antimicrobial Chemotherapy – Antiviral and antifungal drugs

Last updated: 2023/10/21 at 11:55 AM

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Quiz on Antimicrobial Chemotherapy - Antiviral and antifungal drugs:

Drug causing maximum peripheral neuropathy is:

Stavudine

Zidovudine

Didanosine

Lamivudine

None

All of the following are common adverse effects of HAART therapy except:

Steatosis

Increased cholesterol

Optic neuritis

Lipodytrophy

None

Amphotericin B toxicity can be reduced by?

Combining with flucytosine

Incorporating it in liposomal complex

Combining with fluconazole

Injecting the drug with dextrose

None

Which of the following anti-metabolites act as an antifungal agent?

Paclitaxel

Decarbazine

5-Flucytosine (5 FC)

Chlorambucil

None

Drug of choice for chronic hepatitis –B is:

Zidovudine

IFN-alpha

Lamivudine

Ribavirin

None

Enfuvirtide belongs to the class of:

Fusion inhibitors

Gp 120 inhibitors

Protease inhibitors

Nucleotide reverse transcriptase inhibitors

None

Drug of choice in herpes simplex encephalitis is:

Acyclovir

Vidarabine

Amantadine

Interferon

None

Mechanism of action of protease inhibitors is:

Inhibits proviral RNA synthesis

Prevents translation of viral RNA

Causes apoptosis of the affected cells

Prevents maturation of new viral particles

None

Which of the following has poorest oral bioavailability?

Zanamivir

Oseltamivir

Rimantidine

Amantadine

None

10.

The antimicrobial agent which inhibits the ergosterol biosynthesis is:

5-Flucytosine

Amphotericin B

Fluconazole

Griseofulvin

None

11.

A person is being treated for Human Immunodeficiency Virus-1. He developed hypertriglyceridemia and hypercholesterolemia. Most likely drug implicated for these adverse effects is:

Raltegravir

Didanosine

Ritonavir

Efavirenz

None

12.

Treatment of choice for coccidiodomycosis is:

Amphotericin

Flucytosine

Griseofulvin

Fluconazole

None

13.

Drug of choice for herpes simplex keratitis is:

Acyclovir

Ganciclovir

Amantadine

Interferon

None

14.

Mechanism of action of terbinafine is?

Inhition of microtubule formation

Prevents formation of purine

Inhibition of ergosterol synthesis

Binds to ergosterol

None

15.

Drug of choice for acyclovir resistant herpes is:

Gancyclovir

Valacyclovir

Cidofovir

Foscarnet

None

16.

A diabetic patient presents with fungal infection of sinuses and peri-orbital region with significant visual impairment. The best drug for treatment of this patient is:

Itraconazole

Broad spectrum antibiotics

Ketoconazole

Amphotericin B

None

17.

Liposomal amphotericin B has the following advantage over conventional amphotericin B:

Once a week administration

Lesser cost

Absence of infusional toxicity

Lesser nephrotoxicity

None

18.

The drug used to treat acyclovir resistant Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV) infection is:

Foscarnet

Ganciclovir

Valacyclovir

Abacavir

None

19.

The minimum period required for post-exposure chemoprophylaxis for HIV is:

8 weeks

4 weeks

6 weeks

12 weeks

None

20.

Drugs that can be used to treat candida infection are all EXCEPT:

Griseofulvin

Ketoconazole

Amphotericin

Nystatin

None

21.

Which of the following is oral drug for treatment of hepatitis C?

Ledipasvir

Ribamivir

Lamivudine

Peg-interferon

None

22.

Which of the following drugs is used to prevent HIV transmission from an HIV positive pregnant mother to child? (AIIMS Nov. 2011)

Didanosine

Lamivudine

Stavudine

Nevirapine

None

23.

Following drugs act against HIV-2 except:

Ritonavir

Efavirenz

Zalcitabine

Tenofovir

None

24.

Which of the following is most common side effect of zidovudine?

Lactic acidosis

Anemia

Peripheral neuropathy

None

25.

Mechanism of action of oseltamivir is:

Neuraminidase inhibitor

Blocks M2 protein

Apoptosis of respiratory epithelial cells

Block DNA dependent RNA polymerase

None

26.

Pancreatitis is a common complication of which one of the following:

Zalcitabine

Stavudine

Zidovudine

Didanosine

None

27.

Drug of choice for herpes simplex virus infection is:

Acyclovir

Zidovudine

Ribavarin

Indinavir

None

28.

Which drug would treat both dermatophytosis and candidal infections?

Nystatin

Griseofulvin

Tolnaftate

Ketoconazole

None

1 out of 28

Feel free to ask questions and provide any feedback/suggestions by filling in the comment box below.

Thanks for completing the Quiz!

Please note: These MCQs are intended as a general overview of Antimicrobial Chemotherapy - Antiviral Drugs & Antifungal Drugs and are not a comprehensive assessment of the subject.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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