Antimicrobial Chemotherapy – Antiviral and antifungal drugs Last updated: 2023/10/21 at 11:55 AM Pharmacology Mentor 57 Views Share 0 Min Read SHARE Quiz on Antimicrobial Chemotherapy - Antiviral and antifungal drugs: 1. Amphotericin B toxicity can be reduced by? Incorporating it in liposomal complex Combining with fluconazole Combining with flucytosine Injecting the drug with dextrose None 2. A person is being treated for Human Immunodeficiency Virus-1. He developed hypertriglyceridemia and hypercholesterolemia. Most likely drug implicated for these adverse effects is: Raltegravir Efavirenz Didanosine Ritonavir None 3. Which of the following has poorest oral bioavailability? Rimantidine Oseltamivir Amantadine Zanamivir None 4. The minimum period required for post-exposure chemoprophylaxis for HIV is: 12 weeks 4 weeks 6 weeks 8 weeks None 5. Which of the following is most common side effect of zidovudine? Lactic acidosis Peripheral neuropathy Anemia None 6. The antimicrobial agent which inhibits the ergosterol biosynthesis is: Fluconazole 5-Flucytosine Amphotericin B Griseofulvin None 7. Drugs that can be used to treat candida infection are all EXCEPT: Griseofulvin Nystatin Amphotericin Ketoconazole None 8. All of the following are common adverse effects of HAART therapy except: Optic neuritis Lipodytrophy Increased cholesterol Steatosis None 9. The drug used to treat acyclovir resistant Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV) infection is: Abacavir Foscarnet Valacyclovir Ganciclovir None 10. Drug of choice for acyclovir resistant herpes is: Cidofovir Gancyclovir Valacyclovir Foscarnet None 11. A diabetic patient presents with fungal infection of sinuses and peri-orbital region with significant visual impairment. The best drug for treatment of this patient is: Ketoconazole Amphotericin B Itraconazole Broad spectrum antibiotics None 12. Mechanism of action of protease inhibitors is: Prevents translation of viral RNA Inhibits proviral RNA synthesis Causes apoptosis of the affected cells Prevents maturation of new viral particles None 13. Which of the following drugs is used to prevent HIV transmission from an HIV positive pregnant mother to child? (AIIMS Nov. 2011) Didanosine Nevirapine Lamivudine Stavudine None 14. Drug of choice for chronic hepatitis –B is: Zidovudine Lamivudine Ribavirin IFN-alpha None 15. Liposomal amphotericin B has the following advantage over conventional amphotericin B: Once a week administration Lesser cost Lesser nephrotoxicity Absence of infusional toxicity None 16. Pancreatitis is a common complication of which one of the following: Stavudine Didanosine Zalcitabine Zidovudine None 17. Drug causing maximum peripheral neuropathy is: Zidovudine Lamivudine Stavudine Didanosine None 18. Following drugs act against HIV-2 except: Tenofovir Zalcitabine Efavirenz Ritonavir None 19. Drug of choice for herpes simplex virus infection is: Acyclovir Ribavarin Zidovudine Indinavir None 20. Drug of choice in herpes simplex encephalitis is: Amantadine Interferon Acyclovir Vidarabine None 21. Which drug would treat both dermatophytosis and candidal infections? Tolnaftate Ketoconazole Griseofulvin Nystatin None 22. Mechanism of action of terbinafine is? Inhibition of ergosterol synthesis Binds to ergosterol Prevents formation of purine Inhition of microtubule formation None 23. Enfuvirtide belongs to the class of: Fusion inhibitors Nucleotide reverse transcriptase inhibitors Protease inhibitors Gp 120 inhibitors None 24. Drug of choice for herpes simplex keratitis is: Amantadine Acyclovir Ganciclovir Interferon None 25. Which of the following anti-metabolites act as an antifungal agent? 5-Flucytosine (5 FC) Decarbazine Chlorambucil Paclitaxel None 26. Mechanism of action of oseltamivir is: Apoptosis of respiratory epithelial cells Neuraminidase inhibitor Blocks M2 protein Block DNA dependent RNA polymerase None 27. Which of the following is oral drug for treatment of hepatitis C? Lamivudine Ribamivir Ledipasvir Peg-interferon None 28. Treatment of choice for coccidiodomycosis is: Amphotericin Fluconazole Flucytosine Griseofulvin None 1 out of 28 Feel free to ask questions and provide any feedback/suggestions by filling in the comment box below. Thanks for completing the Quiz! Please note: These MCQs are intended as a general overview of Antimicrobial Chemotherapy - Antiviral Drugs & Antifungal Drugs and are not a comprehensive assessment of the subject. Time's up Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition. 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