Antimicrobial Chemotherapy – Antibacterials
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Pharmacology
Antiplatelet drugs, Anticoagulants and Fibrinolytics
Antiplatelet Drugs Antiplatelet drugs are a class of medications that prevent blood clots from forming. They work by stopping your platelets from sticking together. Antiplatelet drugs are used to avoid blood clots, which can cause heart attacks and strokes. • The main component of arterial thrombi is platelets, and the release of chemicals like ADP, TXA2, and … Read more
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Non-steroidal anti-inflammatory drugs (NSAIDs) are cornerstone analgesic, antipyretic, and anti-inflammatory agents whose primary mechanism is inhibition of cyclooxygenase (COX) enzymes to reduce prostaglandin and thromboxane synthesis. A complete pharmacology chapter should cover COX biology, detailed classification, pharmacokinetics/dynamics, therapeutic uses, adverse effects, drug interactions, special populations, and evidence-based risk mitigation strategies from standard pharmacology texts and … Read more
Hematinics and iron chelators
Hematinics are agents that supply essential substrates for erythropoiesis—principally iron, vitamin B12, and folate—while iron chelators remove excess iron from overload states; together, these drugs correct deficiency anemias and mitigate transfusional siderosis when used with appropriate monitoring and route selection. This chapter details classification, mechanisms, pharmacokinetics, indications, dosing, adverse effects, interactions, and evidence-based cautions for … Read more
Pharmacology of Opioid Analgesics
Introduction Opioid analgesics comprise a diverse class of drugs used primarily for pain management. Derived from natural sources such as the opium poppy or synthesized in laboratories, these agents have been used for centuries for their potent analgesic and sedative properties. Opioids remain the most effective agents for controlling intense and certain chronic pain syndromes, … Read more
Sildenafil: Its Use as a PDE5 Inhibitor for Erectile Dysfunction
Phosphodiesterase type 5 (PDE5) inhibitors are first‑line oral agents for erectile dysfunction that augment the endogenous nitric oxide–cGMP pathway in the corpus cavernosum to facilitate erection with sexual stimulation, and the class includes sildenafil, vardenafil, tadalafil, and avanafil. Standard pharmacology texts detail shared mechanisms with clinically important differences in onset, duration, food effects, selectivity, and … Read more
Androgens and Antiandrogens
Androgens are steroid hormones that promote the development and maintenance of male sex characteristics. The principal naturally occurring androgens in humans are testosterone and dihydrotestosterone (DHT), both synthesized mainly in the testes and, to a lesser extent, the adrenal cortex. Androgens bind to intracellular androgen receptors (AR), acting as transcription factors to regulate gene expression … Read more