AntimicrobialPharmacology Antimicrobial Chemotherapy – Antibacterials Last updated: 2023/07/19 at 8:59 PM Pharmacology Mentor 60 Views Share 0 Min Read #Antimicrobial chemotherapy - Antibiotics SHARE Quiz on Antimicrobial Chemotherapy - Antibacterials: 1. Drug of choice for acute meningococcal pyogenic meningitis is: Sulphonamides Chloramphenicol Crystalline penicillin Amoxycillin None 2. Ciprofloxacin should not be given to an asthmatic using theophylline because: Theophylline inhibits ciprofloxacin metabolism Theophylline induces metabolism of ciprofloxacin Ciprofloxacin inhibits theophylline metabolism Ciprofloxacin decreases effect of theophylline None 3. A 21-year-old marathon runner reports to the clinic with acute Achilles tendon rupture. The nurse noted that the patient recently took an antibiotic for community-acquired pneumonia. Which antibiotic may have contributed to tendon rupture? Minocycline Amoxicillin/clavulanate Levofloxacin Cefdinir None 4. Which of the following adverse effects is often employed as a therapeutic use for erythromycin? Deposition in bone Increased gastrointestinal motility Photosensitivity QTc prolongation None 5. Which of the following antibiotic acts by inhibiting cell wall synthesis? Tetracicline Chloramphenicol Erythromycin Gentamicin Penicillin None 6. Redman syndrome is due to: Erythromycin Vancomycin Teicoplanin Rifampicin Polymyxin None 7. A 26 year old patient presents with suspected pneumococcal meningitis. CSF culture is sent for antibiotic sensitivity. Which empirical antibiotic should be given till culture sensitivity result come? Ceftriaxone + metronidazole Doxycycline Cefotaxime + vancomycin Penicillin None 8. A 68-year-old man presents from a nursing home with fever, increased urinary frequency and urgency, and mental status changes. He has a penicillin allergy of anaphylaxis. Which of the following β-lactams is the most appropriate choice for gram-negative coverage of this patient’s urinary tract infection? Cefepime Ertapenem Ceftaroline Aztreonam None 9. Treatment of choice for chancroid is: Chloramphenicol Tetracyclines Erythromycin Penicillin None 10. This bacterial protein synthesis inhibitor is used for management of abdominal abcess caused by Bacteroides fragilis. Antibiotic associated colitis commonly occurs with use of this drug. Which of the following drug is being described? Clindamycin Ticarcillin Clarithromycin Minocycline None 11. In the given below figure at which site does penicillinase work? #Penicillin Site D Site B Site A Site C None 12. Which of the following drugs is used in the treatment of acute bacterial meningitis? Streptomycin Erythromycin Sulfamethoxazole Ceftriaxone None 13. Single dose aminoglycoside administration is more preferable than 8 hourly dose because of: MBC Increase perfusion of renal cortex MIC Post-antibiotic effect Toxicity None 14. Which of the following should be monitored if linezolid is given for more than 14 days? Audiometry Platelet count Liver function tests Kidney function test None 15. Linezolid is best used for: K.pneumoniae MRSA VRSA E.coli None 16. Mechanism of action of fluoroquinolones is: Interferes with intermediary metabolism Inhibits cell wall synthesis Inhibits protein synthesis Inhibits cell membrane synthesis Inhibits DNA gyrase None 17. Drug of choice for prophylaxis of meningococcal meningitis is: Erythromycin Rifampicin Penicillin Septran None 18. A child was admitted to the hospital with H. influenza meningitis. Cefotaxime is preferred over ampicillin because: Cefotaxime is cidal drug whereas ampicillin is bacterostatic Cefotaxime is more active against H influenza having altered penicillin binding proteins Cefotaxime is more active against beta-lactamase producing strains Cefotaxime has more oral bioavailability None 19. Which of the following aminoglycosides has highest nephrotoxicity? Amikacin Streptomycin Neomycin Paramomycin None 20. Drug of choice for antibiotic associated pseudomembranous colitis is: Metronidazole Penicillin G Oral vancomycin Clindamycin None 21. A patient diagnosed as having ventilator associated pneumonia, is on treatment with ceftriaxone and amikacin. Culture and sensitivity turned out to be positive for ESBL producing Klebsiella infection. The most appropriate next action should be: Replace ceftazidime for ceftriaxone Remove amikacin and add quinolone Change over to imipenem Continue same antibiotic but at higher dose None 22. Which one of the following drugs is an antipseudomonal penicillin? Cephalexin Dicloxacillin Cloxacillin Piperacillin None 23. A girl on sulphonamides developed abdominal pain and presented to emergency with seizure. What is the probable cause? Kawasaki’s disease Congenital erythropoietic porphyria Infectious mononucleosis Acute intermittent porphyria None 24. Mechanism of action of vancomycin is: Inhibition of cell wall synthesis Inhibition of DNA gyrase Leakage from cell membrane Inhibition of protein synthesis None 25. Which of the following drugs act by inhibiting bacterial protein synthesis? Streptomycin Monobactams Ethambutol Dapsone Bacitracin None 26. The persistent suppression of bacterial growth that may occur after limited exposure to some antimicrobial drug is called: Sequential blockade Post-antibiotic effect Bactericidal effect Concentration dependent killing Time dependent killing None 27. Erythromycin is drug of choice for treatment of diarrhea in children caused by: Vibrio cholerae Giardia lamblia Staph. aureus Campylobacter jejuni None 28. A post operative patient developed septicemia and was empirically started on combination chemotherapy by a new resident doctor. However, when the patient did not respond even after 10 days of antibiotics treatment, the review of the charts was done. It was found that the resident doctor had started the combination of antibiotics which was mutually antagonistic in action. Which of the following is the most likely combination that was given? Ciprofloxacin and piperacillin Cephalexin and gentamicin Vancomycin and amikacin Ampicillin and chloramphenicol None 29. Drug of choice for prophylaxis of Pneumocystis jiroveci pneumonia in immunocompromised patients is: Cefotetan Cotrimoxazole Dexamethasone Amoxycillin None 30. After 5 days of clindamycin treatment for a skin infection, a patient develops diarrhea (10 watery stools/day), severe abdominal pain, and fever. Which of the following organisms would you be concerned about as the causative pathogen of diarrhea? Clostridium difficile Staphylococcus aureus Bacteroides fragilis C. Escherichia coli None 31. Drug of choice for sore throat caused by Group A beta hemolytic streptococcus is: Erythromycin Sulfonamides Penicillin Ceftriaxone None 32. A 23-year-old man was started on standard four-drug antimycobacterial therapy for treatment of active TB. He has epilepsy, which is controlled with carbamazepine. He has had no seizures in 5 years; however, upon return to clinic at 1 month, he reports having two seizures since his last visit. Which drug may be the reason his carbamazepine is less effective? Ethambutol Pyrazinamide Isoniazid Rifampin None 33. A potent inhibitor of beta-lactamase is: Carbenicillin Clavulanic acid Idoxuridine Amoxicillin Cefamandole None 34. Empirical treatment for meningococcal meningitis is: Gentamicin Ceftriaxone Cefotetan Cefoxitin None 1 out of 34 Feel free to ask questions and provide any feedback/suggestions by filling in the comment box below. Thanks for completing the Quiz! Please note: These MCQs are intended as a general overview of Antimicrobial Chemotherapy - Antibiotics and are not a comprehensive assessment of the subject. Time's up Click here to practice other quizzes on Antiviral, Antifungal, Antimalarial, antiprotozoal and antihelminthic drugs Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition. 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