Endocrine | Pharmacology Mentor

Pharmacotherapy of Type 2 Diabetes

Introduction Type 2 Diabetes Mellitus (T2DM) has become a global health challenge, characterized by insulin resistance and a relative deficiency of insulin secretion, resulting in persistent hyperglycemia. Over time, poorly controlled T2DM can…

Pharmacology Mentor February 8, 2024

Endocrine Pharmacology

Pharmacology of Thionamides

Introduction Among the oldest and most widely used agents for hyperthyroidism, thionamides (alternatively “thioureas”) remain essential in patient care. These medications include propylthiouracil (PTU), methimazole, and carbimazole, commonly referred to as antithyroid or thyroid-inhibiting drugs (Goodman & Gilman, 2018). Their…

Pharmacology Mentor January 26, 2024

Endocrine Pharmacology

Pharmacology of Tamoxifen

Introduction Tamoxifen has emerged as a fundamental drug in oncology, revolutionizing breast cancer treatment and management. Esteemed for both its efficacy and versatility, it has been a mainstay in medical…

Dr. Ambadasu Bharatha January 14, 2024

Endocrine Pharmacology

Pharmacology of Testosterone

Introduction Testosterone is a key hormone in the human body, primarily recognized for its role in male sexual development and secondary sexual characteristics. However, its pharmacological profile extends well beyond basic reproduction…

Pharmacology Mentor December 18, 2023

Endocrine Pharmacology

Pharmacology of thyroid and antithyroid drugs – an Overview

Physiology of Thyroid Hormones Thyroid gland secretes T4 (thyroxine) and T3 (triiodothyronine); T3 is more potent, T4 is a prohormone converted peripherally to T3. Regulation: Hypothalamic-pituitary-thyroid axis (TRH → TSH → thyroid…

Pharmacology Mentor November 11, 2023

Endocrine Pharmacology Reproductive System

Linzagolix Pharmacology and Recent Advancements

Introduction Linzagolix, brand named Yselty®, is a selective, orally administered, non-peptide small molecule gonadotrophin-releasing hormone (GnRH) receptor antagonist developed by Kissei Pharmaceutical, aimed at treating uterine fibroids and endometriosis in…

Pharmacology Mentor November 2, 2023

Endocrine Pharmacology Reproductive System

Pharmacology of Gonadotropin-releasing hormone (GnRH) antagonists

Introduction Gonadotropin-releasing hormone (GnRH) antagonists have redefined several aspects of endocrine and reproductive medicine by offering a more direct and immediate means of suppressing the hypothalamic-pituitary-gonadal (HPG) axis than earlier therapies.…

Pharmacology Mentor October 26, 2023

Endocrine Pharmacology Reproductive System

Gonadotropin-releasing hormone (GnRH) agonists

Gonadotropin-releasing hormone (GnRH) agonists are synthetic peptide analogues of native GnRH engineered to resist enzymatic degradation and to produce sustained receptor activation that ultimately suppresses pituitary LH/FSH and downstream sex…

Pharmacology Mentor October 26, 2023

Endocrine Pharmacology Reproductive System

Pharmacology of Danazol: a synthetic steroid

Introduction and Chemical Nature Danazol is a synthetic isoxazole derivative of 17α-ethinyl testosterone. It was developed for its unique endocrine properties and mild androgenic activity, making it useful in various gynecological…

Pharmacology Mentor October 26, 2023

Endocrine Pharmacology

Physiology of the Thyroid Gland

#thyroid drugs Introduction The thyroid gland plays a pivotal role in human physiology, modulating metabolism, growth, and development through the production and secretion of thyroid hormones. These hormones, primarily triiodothyronine (T3) and thyroxine (T4), influence virtually…

Pharmacology Mentor September 29, 2023

Pharmacotherapy of Type 2 Diabetes

Pharmacology of Thionamides

Pharmacology of Tamoxifen

Pharmacology of Testosterone

Pharmacology of thyroid and antithyroid drugs – an Overview

Linzagolix Pharmacology and Recent Advancements

Pharmacology of Gonadotropin-releasing hormone (GnRH) antagonists

Gonadotropin-releasing hormone (GnRH) agonists

Pharmacology of Danazol: a synthetic steroid

Physiology of the Thyroid Gland

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