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Pharmacology Mentor > Anticoagulants, antiplatelet drugs and fibrinolytics

Anticoagulants, antiplatelet drugs and fibrinolytics

Last updated: 2024/04/15 at 6:46 PM

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Quiz on Anticoagulants, antiplatelet drugs and fibrinolytics:

Mechanism of action of aspirin as antiplatelet drug is its inhibitory action on?

Prostacyclins

Phospholipase C

PGF 2 alpha

Thromboxane A2

None

The anticoagulant of choice in pregnancy is:

Heparin

Dicumarol

Warfarin

Phenindione

None

In low dose aspirin acts on:

Thromboxane A2 synthase

Cyclooxygenase

Lipoxygenase

PGI2 synthase

None

Drug used in heparin overdose is:

Clopidogrel

Ticlopidine

Protamine sulfate

Phylloquinone

None

Recent oral direct thrombin inhibitor which can be used for prevention of stroke is:

Saxagliptin

Dabigatran

Lepirudin

Ximelagatran

None

Abciximab is:

Antibody against Ilb/Illa receptors

Adenosine inhibitor

Antibody against Ib/IX receptors

Topoisomerase inhibitor

None

Anticoagulant of choice for heparin induced thrombocytopenia is?

Lepirudin

Plasminogen

Abciximab

Aprotinin

None

Ticlopidine act by:

GP IIb/IIIa antagonist

Decreasing ADP mediated cAMP activation

Phosphodiesterase inhibition

Inhibiting COX enzyme irreversibly

None

A patient of thrombosis of veins has been receiving coumarin therapy for three years. Recently she developed bleeding tendency. How will you reverse the effect of coumarin therapy?

Infusion of fibrinogen

Vit K injection

Whole blood transfusion

Protamine injection

None

10.

Glycoprotein IIb/IIIa receptor antagonist is:

Clopidogrel

Ticlopidine

Tranexamic acid

Abciximab

None

11.

Oral anticoagulants are monitored by:

Bleeding time (BT)

Coagulation time (CT)

Prothrombin time (PT)

Partial thromboplastin time (PTT)

None

12.

Antidote of fibrinolytic drugs is:

Protamine

Epsilon amino caproic acid

Heparin

Alteplase

None

13.

Mechanism of action of clopidogrel is:

Phosphodiesterase inhibition

Thromboxane A2 inhibition

Inhibit ADP mediated cAMP activation

GP IIb/IIIa inhibition

None

14.

A diabetic female on INH and rifampicin for TB developed DVT. She was started on warfarin, PT is not raised, and next step should be:

Replace warfarin with acenocoumarin

Use LMW heparin

Increase the dose of warfarin

Switch ethambutol for rifampicin

None

15.

Which of the following substance can be used as anantidote to fibrinolytics?

Protamine

Epsilon Amino Caproic Acid

Alteplase

Dabigatran

None

16.

Aspirin prolongs bleeding by inhibiting the synthesis of which of the following?

Thromboxane A2

Adenosine receptors

Prostacyclin

Cyclic AMP

None

17.

Which of the following drug is NOT a GpIIb/IIIa antagonist?

Tirofiban

Eptifibatide

Abciximab

Prasugrel

None

18.

Aspirin is not given in a patient who is already on heparin because aspirin causes:

Aspirin inhibits the action of heparin

Enhanced hypersensitivity of heparin

Platelet dysfunction

Therapy of heparin cannot be monitored

None

19.

The most common adverse effect with ticlopidine is:

Neutropenia

Thrombocytopenic purpura

Diarrhea

Hemorrhage

None

20.

As compared to unfractionated heparin, low molecular weight heparins:

Require more frequent laboratory monitoring

Predispose to a higher risk of osteopenia

Can be given to patients with heparin induced thrombocytopenia

Are absorbed more uniformly when given subcutaneously

None

21.

LMW heparin is preferred over unfractionated heparin because:

LMW heparins have lesser risk of causing bleeding

LMW heparin directly inhibits thrombin whereas unfractionated heparin acts via activation of antithrombin

LMW heparin has consistent bioavailability

LMW heparin can be given subcutaneously as well as orally

None

22.

Apixaban is a new drug that acts by:

Activating plasminogen

Inhibiting coagulation factor Xa

Inhibiting platelet aggregation

Inhibiting TNF alpha

None

1 out of 22

Thanks for completing the Quiz!

Please note: These MCQs are intended as a general overview of Anticoagulants, antiplatelet drugs and fibrinolytics and are not a comprehensive assessment of the subject.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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