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amiodarone-pharmacologymentor
Posted inCVS Pharmacology

Antiarrhythmic drugs: Class III – Amiodarone and others

#Amiodarone Structure Class III antiarrhythmics predominantly prolong cardiac repolarization via potassium channel blockade, with amiodarone as the prototypical agent and additional options including dofetilide, sotalol, ibutilide, and dronedarone chosen based on structural…
Read More Antiarrhythmic drugs: Class III – Amiodarone and others
Posted by Pharmacology Mentor September 17, 2023
antiarrhythmic drugs
Posted inCVS Pharmacology

Antiarrhythmic drugs: Beta-adrenoceptor-blocking drugs (Class 2)

Introduction Among the diverse categories of drugs used to manage cardiac arrhythmias, beta-adrenoceptor-blocking drugs (beta blockers)—classified as Class 2 antiarrhythmics under the Vaughan Williams scheme—play a pivotal role in controlling aberrant…
Read More Antiarrhythmic drugs: Beta-adrenoceptor-blocking drugs (Class 2)
Posted by Pharmacology Mentor September 17, 2023
propafenone
Posted inCVS Pharmacology

Antiarrhythmic drugs: Propafenone (Class 1C)

Propafenone is a Class 1C antiarrhythmic that produces potent, use‑dependent blockade of fast cardiac Na+ channels with slow unbinding kinetics, resulting in marked conduction slowing and QRS widening, and it…
Read More Antiarrhythmic drugs: Propafenone (Class 1C)
Posted by Pharmacology Mentor September 17, 2023
Flecainide
Posted inCVS Pharmacology

Antiarrhythmic drugs: Flecainide (Class 1C)

Flecainide is a Class 1C antiarrhythmic agent widely used for rhythm control in atrial and ventricular arrhythmias, particularly in patients without significant structural heart disease. The following summarizes its pharmacology, clinical…
Read More Antiarrhythmic drugs: Flecainide (Class 1C)
Posted by Pharmacology Mentor September 17, 2023
Mexiletine
Posted inCVS Pharmacology

Antiarrhythmic drugs: Mexiletine (Class 1B)

Mexiletine is an oral Class IB antiarrhythmic and sodium channel blocker structurally related to lidocaine, used primarily for ventricular arrhythmias and selected channelopathies such as LQT3 where late sodium current…
Read More Antiarrhythmic drugs: Mexiletine (Class 1B)
Posted by Pharmacology Mentor September 17, 2023
lidocaine
Posted inCVS Pharmacology

Antiarrhythmic drugs: Lidocaine (Class 1B)

If you trained in a time when every crash cart seemed to include “lido,” you remember lidocaine as the go-to antidote for ugly ventricular ectopy. Today, it has a more…
Read More Antiarrhythmic drugs: Lidocaine (Class 1B)
Posted by Pharmacology Mentor September 17, 2023
Disopyramide
Posted inCVS Pharmacology

Antiarrhythmic drugs: Disopyramide (Class 1A)

Introduction Disopyramide is a Class 1a antiarrhythmic agent, primarily used in the treatment of ventricular tachycardia. It functions as a sodium channel blocker, inhibiting conduction by depressing the increase in…
Read More Antiarrhythmic drugs: Disopyramide (Class 1A)
Posted by Pharmacology Mentor September 17, 2023
Quinidine
Posted inCVS Pharmacology

Antiarrhythmic drugs: Quinidine (Class 1A)

Overview and Learning Objectives By the end of this chapter, you should be able to: Describe the chemical origin, classification, and electrophysiologic actions of quinidine. Explain its pharmacokinetics, pharmacodynamics, and…
Read More Antiarrhythmic drugs: Quinidine (Class 1A)
Posted by Pharmacology Mentor September 17, 2023
Procainamide
Posted inCVS Pharmacology

Antiarrhythmic drugs: Procainamide (Class 1A)

Procainamide is a Class IA antiarrhythmic that blocks fast INaINa channels and prolongs repolarization via its active metabolite N-acetylprocainamide (NAPA), making it useful for acute management of a variety of ventricular and…
Read More Antiarrhythmic drugs: Procainamide (Class 1A)
Posted by Pharmacology Mentor September 17, 2023
Carbonic Anhydrase Inhibitors
Posted inCVS Pharmacology

Pharmacology of Carbonic Anhydrase Inhibitors

I. Introduction and Class Overview Carbonic anhydrase inhibitors (CAIs) are a class of drugs that reversibly inhibit the enzyme carbonic anhydrase, thereby interfering with HCO₃⁻ (bicarbonate) reabsorption and decreasing hydrogen…
Read More Pharmacology of Carbonic Anhydrase Inhibitors
Posted by Pharmacology Mentor August 31, 2023

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