Clindamycin is a semi-synthetic lincosamide antibiotic that exerts its antimicrobial action by binding to the 23S rRNA of the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis through blockage of peptide bond formation and interference with translocation. This results predominantly in a bacteriostatic effect, though bactericidal activity may be observed at higher concentrations against certain … Read more
Introduction Vancomycin is a prominent glycopeptide antibiotic widely recognized for its efficacy in treating severe infections caused by Gram-positive bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA) and certain Clostridioides difficile (C. diff) infections. Its critical role in modern medicine stems from an increasing need to address challenging and resistant microbial pathogens that threaten patient safety in … Read more
The development of antimicrobial agents stands as one of the most significant achievements in medical history. From ancient remedies to the modern era of targeted chemotherapeutics, the journey of these life-saving drugs illustrates remarkable ingenuity, scientific progress, and ongoing challenges such as antimicrobial resistance. Early Observations and Ancient Remedies Humans used moulds, plant extracts, and … Read more