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Pharmacology Mentor > Anticoagulants, antiplatelet drugs and fibrinolytics

Anticoagulants, antiplatelet drugs and fibrinolytics

Last updated: 2024/04/15 at 6:46 PM

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Quiz on Anticoagulants, antiplatelet drugs and fibrinolytics:

Glycoprotein IIb/IIIa receptor antagonist is:

Tranexamic acid

Ticlopidine

Clopidogrel

Abciximab

None

The anticoagulant of choice in pregnancy is:

Warfarin

Phenindione

Dicumarol

Heparin

None

Antidote of fibrinolytic drugs is:

Alteplase

Protamine

Heparin

Epsilon amino caproic acid

None

The most common adverse effect with ticlopidine is:

Diarrhea

Hemorrhage

Neutropenia

Thrombocytopenic purpura

None

LMW heparin is preferred over unfractionated heparin because:

LMW heparin directly inhibits thrombin whereas unfractionated heparin acts via activation of antithrombin

LMW heparins have lesser risk of causing bleeding

LMW heparin has consistent bioavailability

LMW heparin can be given subcutaneously as well as orally

None

Mechanism of action of aspirin as antiplatelet drug is its inhibitory action on?

Thromboxane A2

Prostacyclins

PGF 2 alpha

Phospholipase C

None

Aspirin prolongs bleeding by inhibiting the synthesis of which of the following?

Adenosine receptors

Cyclic AMP

Thromboxane A2

Prostacyclin

None

Which of the following substance can be used as anantidote to fibrinolytics?

Epsilon Amino Caproic Acid

Alteplase

Dabigatran

Protamine

None

Anticoagulant of choice for heparin induced thrombocytopenia is?

Lepirudin

Aprotinin

Abciximab

Plasminogen

None

10.

Ticlopidine act by:

Phosphodiesterase inhibition

Decreasing ADP mediated cAMP activation

GP IIb/IIIa antagonist

Inhibiting COX enzyme irreversibly

None

11.

Aspirin is not given in a patient who is already on heparin because aspirin causes:

Enhanced hypersensitivity of heparin

Therapy of heparin cannot be monitored

Platelet dysfunction

Aspirin inhibits the action of heparin

None

12.

As compared to unfractionated heparin, low molecular weight heparins:

Predispose to a higher risk of osteopenia

Are absorbed more uniformly when given subcutaneously

Can be given to patients with heparin induced thrombocytopenia

Require more frequent laboratory monitoring

None

13.

Mechanism of action of clopidogrel is:

Phosphodiesterase inhibition

Thromboxane A2 inhibition

Inhibit ADP mediated cAMP activation

GP IIb/IIIa inhibition

None

14.

Apixaban is a new drug that acts by:

Inhibiting platelet aggregation

Activating plasminogen

Inhibiting coagulation factor Xa

Inhibiting TNF alpha

None

15.

A diabetic female on INH and rifampicin for TB developed DVT. She was started on warfarin, PT is not raised, and next step should be:

Switch ethambutol for rifampicin

Increase the dose of warfarin

Replace warfarin with acenocoumarin

Use LMW heparin

None

16.

Drug used in heparin overdose is:

Clopidogrel

Protamine sulfate

Ticlopidine

Phylloquinone

None

17.

In low dose aspirin acts on:

Thromboxane A2 synthase

PGI2 synthase

Lipoxygenase

Cyclooxygenase

None

18.

Which of the following drug is NOT a GpIIb/IIIa antagonist?

Eptifibatide

Abciximab

Prasugrel

Tirofiban

None

19.

Abciximab is:

Adenosine inhibitor

Topoisomerase inhibitor

Antibody against Ib/IX receptors

Antibody against Ilb/Illa receptors

None

20.

A patient of thrombosis of veins has been receiving coumarin therapy for three years. Recently she developed bleeding tendency. How will you reverse the effect of coumarin therapy?

Infusion of fibrinogen

Whole blood transfusion

Vit K injection

Protamine injection

None

21.

Recent oral direct thrombin inhibitor which can be used for prevention of stroke is:

Ximelagatran

Lepirudin

Saxagliptin

Dabigatran

None

22.

Oral anticoagulants are monitored by:

Partial thromboplastin time (PTT)

Prothrombin time (PT)

Bleeding time (BT)

Coagulation time (CT)

None

1 out of 22

Thanks for completing the Quiz!

Please note: These MCQs are intended as a general overview of Anticoagulants, antiplatelet drugs and fibrinolytics and are not a comprehensive assessment of the subject.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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