Malaria ✓ Passing Score: 50% 📝 Questions: 10 🎓 Practice Quiz Welcome! This is a practice quiz to test your knowledge. Please enter your details below to participate. Your results will be emailed to you upon completion. Your Information Name * Email * Start Quiz → Question 1 of 10 1 A 5‑year‑old boy with confirmed P. vivax malaria is found to have a positive G6PD screening test. Which antimalarial regimen is safest for radical cure? * Atovaquone‑proguanil 250 mg/100 mg PO twice daily for 7 days Doxycycline 100 mg PO daily for 4 days Chloroquine 25 mg/kg PO daily for 3 days Artemisinin‑based combination therapy alone Primaquine 0.5 mg/kg PO daily for 14 days 2 What is the typical plasma half‑life of chloroquine in patients with uncomplicated malaria? * 7–10 days 30–40 days 12–18 hours 1–2 days 2–4 hours 3 A 24‑year‑old man with severe P. falciparum malaria develops generalized tonic‑clonic seizures. Which adjunctive therapy is recommended? * Oral levetiracetam 500 mg twice daily Oral valproic acid 250 mg twice daily IV magnesium sulfate 4 g over 15 min IV diazepam 10 mg IV phenytoin 50 mg/kg 4 A 32‑year‑old woman from a malaria‑endemic region presents with fever, chills, headache, and mild anemia (Hb = 10 g/dL). Blood smear shows *Plasmodium falciparum* parasites. Which regimen is most appropriate for uncomplicated falciparum malaria? * Ivermectin 200 µg/kg PO once Atovaquone‑proguanil 250 mg/100 mg PO twice daily for 7 days Quinine 10 mg/kg PO q8h for 7 days Artemether‑lumefantrine 20 mg/120 mg PO twice daily for 3 days Chloroquine 25 mg/kg PO daily for 3 days 5 A 45‑year‑old man with known P. falciparum infection presents with fever, hypotension (BP = 85/50 mm Hg), tachycardia, oliguria, and a capillary refill time 4 s. Labs reveal hemoglobin 8 g/dL, platelets 70 × 10⁹/L, creatinine 2.0 mg/dL, and lactate 4 mmol/L. Which is the best initial antimalarial therapy? * Chloroquine 25 mg/kg PO daily for 3 days IV quinine 10 mg/kg q8h for 7 days Oral artemether‑lumefantrine 20 mg/120 mg PO twice daily for 3 days IV artesunate 2.4 mg/kg IV q8h for 24 h, then switch to oral ACT Oral atovaquone‑proguanil 250 mg/100 mg PO twice daily for 7 days 6 Antimalarial drugs are classified into several groups based on the life cycle stage they target. Which drug class primarily acts against the hepatic hypnozoite stage of P. vivax? * Artemisinin‑based combinations 5‑chloro-6‑methoxyluracil derivatives (primaquine, tafenoquine) Nucleoside analogs (azithromycin, doxycycline) 4‑aminoquinolines (chloroquine, amodiaquine) Aromatic amino alcohols (quinine, mefloquine) 7 A 52‑year‑old man with P. vivax malaria is prescribed primaquine 0.5 mg/kg PO daily for 14 days. He is also taking clopidogrel for coronary artery disease. Which statement is most accurate regarding this drug interaction? * Primaquine is a potent CYP3A4 inhibitor, raising clopidogrel levels. Clopidogrel induces CYP2D6, increasing primaquine metabolism and reducing efficacy. There is no clinically significant interaction between primaquine and clopidogrel. Clopidogrel inhibits CYP2D6, decreasing primaquine activation and increasing hemolysis risk. Primaquine enhances clopidogrel’s antiplatelet effect, increasing bleeding risk. 8 Which of the following best describes the mechanism of action of artemisinin derivatives in the treatment of malaria? * Inhibition of dihydrofolate reductase, preventing DNA synthesis Blocking the cytochrome bc1 complex, inhibiting electron transport Generation of reactive oxygen species via heme‑activated cleavage of endoperoxide bridge Inhibition of protein synthesis by binding to the 50S ribosomal subunit Inhibition of PfATP6 calcium ATPase, disrupting parasite calcium homeostasis 9 A 28‑year‑old pregnant woman in her 2nd trimester (20 weeks) presents with fever, chills, and a positive rapid diagnostic test for P. falciparum. Which antimalarial is preferred? * Artemether‑lumefantrine 20 mg/120 mg PO twice daily for 3 days Primaquine 0.5 mg/kg PO daily for 14 days Atovaquone‑proguanil 250 mg/100 mg PO twice daily for 7 days Chloroquine 25 mg/kg PO daily for 3 days Quinine 10 mg/kg PO q8h for 7 days 10 A 35‑year‑old woman with confirmed P. falciparum malaria is started on artemether‑lumefantrine. Laboratory monitoring shows a rising platelet count and a normal bilirubin level. Which parameter is most important to monitor for lumefantrine therapy? * Serum creatinine Hemoglobin A1c Blood glucose Liver transaminases (AST/ALT) Serum potassium ← Previous Next → Submit Quiz ✓
