Introduction Proton pump inhibitors (PPIs) have revolutionized the management of acid-related gastrointestinal (GI) disorders by rendering potent and long-lasting suppression of gastric acid secretion. Introduced in the late twentieth century, PPIs—exemplified by omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole, and dexlansoprazole—effectively mitigate gastric hyperacidity,…