Antiarrhythmic drugs: Lidocaine (Class 1B)
If you trained in a time when every crash cart seemed to include “lido,” you remember lidocaine as the go-to antidote for ugly ventricular ectopy. Today, it has a more…
Antiarrhythmic drugs: Disopyramide (Class 1A)
Introduction Disopyramide is a Class 1a antiarrhythmic agent, primarily used in the treatment of ventricular tachycardia. It functions as a sodium channel blocker, inhibiting conduction by depressing the increase in…
Antiarrhythmic drugs: Quinidine (Class 1A)
Overview and Learning Objectives By the end of this chapter, you should be able to: Quinidine is a prototypical Class IA antiarrhythmic historically used in atrial and ventricular arrhythmias. Although…
Antiarrhythmic drugs: Procainamide (Class 1A)
Procainamide is a Class IA antiarrhythmic that blocks fast INaINa channels and prolongs repolarization via its active metabolite N-acetylprocainamide (NAPA), making it useful for acute management of a variety of ventricular and…
Classification of Adrenergic Receptors: A Quick Overview
Introduction Adrenergic receptors play a pivotal role in regulating physiological processes and are the target of numerous pharmacological interventions. These receptors are broadly classified into α and β types, with…
Adverse Drug Reactions: On-target and Off-target aspect
Introduction Adverse drug reactions (ADRs) remain a formidable challenge in clinical pharmacology and patient care. They can significantly diminish quality of life, induce severe morbidity and mortality, extend hospital stays,…
The History of Pharmacology
The Intersection of Religion and Medicine At the dawn of human civilization, religion and medicine were inextricably linked. Priests, shamans, and holy people were the original pharmacologists, wielding the power…
Pharmacokinetic Principles: A Comprehensive Guide
Introduction Pharmacokinetics is the science that describes how drugs move within the body and is crucial for rational dosing in clinical settings. This article aims to provide a comprehensive understanding…
Navigating the Complex Landscape of Drug Targets: From Validation to Druggability
Introduction The journey from drug discovery to market is a complex and intricate process, often fraught with challenges and uncertainties. One of the most critical aspects of this journey is…
Pharmacodynamic Principles: A Dive into Receptors and Binding Sites
Introduction Pharmacodynamics is the study of how drugs interact with biological systems, specifically focusing on the effects of drugs on the body. One of the most critical aspects of pharmacodynamics…
