Alpha agonists ✓ Passing Score: 50% 📝 Questions: 12 🎓 Practice Quiz Welcome! This is a practice quiz to test your knowledge. Please enter your details below to participate. Your results will be emailed to you upon completion. Your Information Name * Email * Start Quiz → Question 1 of 12 1 Which receptor subtype is primarily responsible for peripheral vasoconstriction mediated by norepinephrine? * $\\text{M}_3$ $\\alpha_2$ $\\beta_2$ $\\beta_1$ $\\alpha_1$ 2 What is the primary reason why pure $\\alpha$ agonists are generally avoided for treating shock or heart failure compared to agents with mixed $\\alpha$ and $\\beta$ activity (like epinephrine)? * $\\alpha$ agonists cause too much bradycardia. $\\alpha$ agonists are highly cardiotoxic. $\\alpha$ agonists are exclusively centrally acting. $\\alpha$ agonists lack the necessary inotropic/chronotropic effects. $\\alpha$ agonists only cause vasodilation. 3 Which of the following drugs is an $\\alpha_2$ agonist used clinically to treat hypertension? * Epinephrine Metaraminol Yohimbine Clonidine Prazosin 4 Which drug is an $\\alpha_2$ *antagonist* that can potentially increase sympathetic tone and elevate blood pressure? * Yohimbine Midodrine Tamsulosin Dexmedetomidine Norepinephrine 5 Midodrine is an orally active drug used to treat orthostatic hypotension. It exerts its therapeutic effect primarily through which receptor mechanism? * Peripheral $\\alpha_1$ stimulation Inhibition of norepinephrine reuptake Central $\\alpha_2$ stimulation $\\beta_1$ agonism $\\alpha_2$ antagonism 6 Which receptor subtype is mainly responsible for the mydriasis (pupil dilation) effect seen with topical epinephrine application to the eye? * $\\text{M}_2$ $\\alpha_2$ $\\beta_1$ $\\alpha_1$ $\\beta_2$ 7 Which statement accurately describes the effect of an $\\alpha_1$ agonist on the prostate gland smooth muscle tone? * It causes relaxation, facilitating urine flow. It stimulates $\\beta_3$ receptors causing contraction. It has no effect on prostate smooth muscle. It primarily affects the detrusor muscle, not the prostate. It causes contraction, worsening urinary obstruction. 8 Dexmedetomidine, a highly selective $\\alpha_2$ agonist, is often used in anesthesia for its sedative and analgesic properties. What is a common cardiovascular side effect associated with its use? * Severe hypotension and bradycardia Sustained hypertension Tachyphylaxis Bronchoconstriction Profound peripheral vasodilation 9 The mechanism of action for presynaptic $\\alpha_2$ receptors on sympathetic nerve terminals is best described as: * Inhibiting the release of acetylcholine Enhancing the release of norepinephrine Stimulating postsynaptic $\\beta$ receptors Inhibiting the release of norepinephrine Inhibiting the reuptake of serotonin 10 A major side effect of systemically administered high-dose $\\alpha_1$ agonists used for vasopressor support might include: * Bronchospasm Bradycardia Hypoglycemia Reflex tachycardia Hypotension 11 Activation of central $\\alpha_2$ receptors in the brainstem primarily leads to which physiological effect? * Bronchodilation Increased sympathetic outflow Decreased blood pressure Pupil dilation Decreased heart rate 12 Which drug is a highly selective $\\alpha_1$ agonist commonly used as a topical nasal decongestant? * Dobutamine Phenylephrine Isoproterenol Clonidine Phentolamine ← Previous Next → Submit Quiz ✓
