Spironolactone

Pharmacology of Potassium-Sparing Diuretics

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Potassium-sparing diuretics

Potassium-sparing diuretics are a class of diuretic medications that increase diuresis (urine production) while conserving potassium, contrasting with thiazide and loop diuretics that promote potassium loss. They are used primarily to counteract hypokalemia and as adjuncts in conditions involving excessive fluid retention or aldosterone excess. Classification and Key Agents Class Main Drugs Site of Action … Read more

Androgens and Antiandrogens

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androgens and antiandrogens

Androgens are steroid hormones that promote the development and maintenance of male sex characteristics. The principal naturally occurring androgens in humans are testosterone and dihydrotestosterone (DHT), both synthesized mainly in the testes and, to a lesser extent, the adrenal cortex. Androgens bind to intracellular androgen receptors (AR), acting as transcription factors to regulate gene expression … Read more