Introduction Skeletal muscle relaxants are a diverse group of medications that act on the central nervous system (CNS) or directly on skeletal muscles to reduce muscle tone and alleviate symptoms such as muscle spasms, pain, and hyperreflexia (Katzung & Trevor, 2021). These drugs are commonly used in various clinical settings, including anaesthesia, neurology, and pain … Read more
Introduction The neuromuscular junction (NMJ) is a specialized synapse where a motor neuron communicates with a skeletal muscle fiber to initiate muscle contraction. This communication relies on the release of acetylcholine (ACh) from the presynaptic terminal of the motor neuron, the subsequent binding of ACh to nicotinic receptors on the postsynaptic muscle membrane, and the resultant end-plate potential that triggers muscle contraction. Neuromuscular junction (NMJ) blockers—also referred to … Read more
Vecuronium is a non-depolarizing neuromuscular blocking agent utilized for muscle relaxation during surgical procedures or as an adjunct in general anesthesia. Here’s a detailed breakdown of its pharmacology: Classification Mechanism of Action: Pharmacokinetics Indications Adverse Effects Drug Interactions Special Populations This thorough analysis of Vecuronium’s pharmacology underscores its mechanism of action, pharmacokinetics, clinical uses, and … Read more