Pharmacology of Proton Pump Inhibitors
Introduction Proton pump inhibitors (PPIs) have revolutionized the management of acid-related gastrointestinal (GI) disorders by rendering potent and long-lasting suppression of gastric acid secretion. Introduced in the late twentieth century, PPIs—exemplified by omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole, and dexlansoprazole—effectively mitigate gastric hyperacidity, enabling healing of peptic ulceration and alleviation of reflux symptoms (Katzung, 2020). Used extensively for indications ranging from peptic ulcer disease (PUD) and gastroesophageal reflux … Read more