kinetics

First-Order vs. Zero-Order Kinetics: What You Need to Know

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first-order vs zero-order kinetics

Zero-Order Kinetics Definition: In zero-order kinetics, the rate of drug elimination is constant and does not depend on the drug concentration. This is often seen with drugs that saturate the body’s ability to metabolize or eliminate them. Equation: The rate equation for zero-order kinetics is: Where (k) is the rate constant. Clinical Importance: Zero-order kinetics … Read more

Kinetics of Elimination: A Complete Overview of Mechanisms and Implications

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kinetics of elimination

Understanding the kinetics of how a drug is removed from the body is foundational for creating and adjusting rational dosage plans tailored to individual patient needs. Three key pharmacokinetic parameters must be comprehended: bioavailability (F), volume of distribution (Vd), and clearance (CL). The first two have been previously discussed. Drug Elimination Drug elimination comprises both … Read more