Pharmacology of Prostaglandin Analogues

prostaglandin analogues

I. Introduction Prostaglandins are autacoids derived from arachidonic acid via the cyclooxygenase pathway and modulate numerous physiological processes—vascular tone, inflammation, gastric cytoprotection, uterine contraction, and intraocular pressure. Prostaglandin analogues are synthetic structural or functional mimetics designed to replicate or enhance one or more actions of natural prostaglandins, often with improved pharmacokinetics and receptor selectivity. Their … Read more

Glaucoma, pathophysiology, treatment and other information

Glaucoma Illustration showing open-angle glaucoma eye anatomy in cartoon style

Glaucoma is a chronic, progressive optic neuropathy characterized by retinal ganglion cell loss and characteristic optic nerve/visual field damage in which lowering intraocular pressure (IOP) slows progression across open‑angle, angle‑closure, and secondary forms. The only proven disease‑modifying therapy is sustained IOP reduction via medications, laser trabeculoplasty, or surgery tailored to mechanism, severity, and risk, with … Read more