Pharmacology of GLP-1 Agonists
1. Introduction: The Incretin Effect To understand GLP-1 agonists, one must first understand the “Incretin Effect.” This physiological phenomenon describes the observation that oral glucose administration elicits a much higher insulin response than an isoglycemic intravenous (IV) glucose infusion. In Type 2 Diabetes Mellitus (T2DM), the incretin effect is significantly blunted, predominantly due to a … Read more