Danazol | Pharmacology Mentor

Pharmacology of Danazol: a synthetic steroid

October 6, 2025October 26, 2023 by Pharmacology Mentor

Introduction and Chemical Nature Danazol is a synthetic isoxazole derivative of 17α-ethinyl testosterone. It was developed for its unique endocrine properties and mild androgenic activity, making it useful in various gynecological and hematological conditions. Structurally, its modifications confer the ability to suppress gonadotropin secretion and interact with multiple steroid receptors. Mechanism of Action Danazol exerts a … Read more

Androgens and Antiandrogens

October 6, 2025January 30, 2023 by Pharmacology Mentor

Androgens are steroid hormones that promote the development and maintenance of male sex characteristics. The principal naturally occurring androgens in humans are testosterone and dihydrotestosterone (DHT), both synthesized mainly in the testes and, to a lesser extent, the adrenal cortex. Androgens bind to intracellular androgen receptors (AR), acting as transcription factors to regulate gene expression … Read more