Pharmacology of Clindamycin

Clindamycin

Clindamycin is a semi-synthetic lincosamide antibiotic that exerts its antimicrobial action by binding to the 23S rRNA of the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis through blockage of peptide bond formation and interference with translocation. This results predominantly in a bacteriostatic effect, though bactericidal activity may be observed at higher concentrations against certain … Read more

Clindamycin: a lincosamide antibiotic

Clindamycin

Clindamycin is a lincosamide antibiotic widely used for its excellent activity against many Gram-positive cocci and anaerobes. It is valued for oral and parenteral versatility, tissue penetration (including bone), and its toxin-suppressing action in severe streptococcal and staphylococcal infections. Chemistry & Mechanism Clindamycin is a semi-synthetic chlorinated derivative of lincomycin. It binds to the 23S ribosomal … Read more