Pharmacology of H2 Receptor Antagonists
Histamine H2 receptor antagonists are competitive blockers of gastric parietal-cell H2 receptors that suppress basal and stimulated acid secretion and are used for GERD, peptic ulcer disease, hypersecretory states, and selected prophylaxis indications, with famotidine preferred clinically because of potency and safety while ranitidine has been withdrawn for NDMA contamination concerns. The class reduces nocturnal … Read more