Pharmacology of Histamine and Antihistamines

antihistamine

Overview Histamine is a ubiquitous biogenic amine that influences vascular tone and permeability, sensory nerve activity (especially itch), airway smooth muscle, gastric acid secretion, and central nervous system arousal. Among its diverse receptor subtypes (H1–H4), the H1 receptor is the dominant mediator of the hallmark symptoms of immediate-type (type I) allergic reactions in the skin … Read more