Organophosphorus Compound Poisoning and Its Treatment

Organophosphorous compound poisoning

Introduction Organophosphorus (OP) compounds, a broad class of chemicals primarily used as pesticides (insecticides) and, less ethically, as chemical warfare agents (nerve gases), pose a significant challenge in both developed and developing nations (Katzung, 2020). Poisoning from OP agents remains a leading cause of acute morbidity and mortality worldwide, particularly in rural settings where pesticides are extensively deployed in … Read more

Atropine/Belladonna/Datura Poisoning: Causes, Symptoms, and Treatment

atropine - belladonna poisoning

1 · Overview Atropine, hyoscyamine and scopolamine are tropane alkaloids concentrated in plants of the Solanaceae family—most notably Atropa belladonna (deadly nightshade) and Datura stramonium (jimson-weed). These compounds act as potent competitive antagonists at muscarinic acetylcholine receptors, producing the classic “anticholinergic toxidrome.” Untreated, severe poisoning may culminate in seizures, hyperthermia, rhabdomyolysis, dysrhythmia or respiratory failure … Read more