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Pharmacology Mentor > Hematinics and Iron Chelators

Hematinics and Iron Chelators

Last updated: 2024/04/15 at 6:46 PM

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Quiz on Hematinics and Iron Chelators:

1.

What is the formula for parenteral iron therapy:

3.3 × body weight (kg) × Hb deficit (g/dl)

1.1 × body weight (kg) × Hb deficit (g/dl)

2.2 × body weight (kg) × Hb deficit (g/dl)

4.4 × body weight (kg) × Hb deficit (g/dl)

None

2.

Filgrastim is used for the treatment of:

Neutrophilia

Polycythemia

Neutropenia

Anemia

None

3.

Iron is most commonly absorbed from:

Lower jejunum

Stomach

Ileum

Duodenum and upper jejunum

None

4.

All of the following are characteristic features of treatment of iron deficiency anemia with oral iron supplements, EXCEPT:

The treatment should be discontinued immediately once hemoglobin normalizes to prevent side effects of iron

If 200-300 mg elemental iron is consumed, about 50 mg is absorbed

The reticulocyte count should begin to increase in two weeks and peak in 4 weeks—this suggests good response to treatment

The proportion of iron absorbed reduces as hemoglobin improves

None

5.

Filgrastim is a:

T-cell stimulating factor

GnRH analogue

GM-CSF

G-CSF

None

6.

The most appropriate drug used for chelation therapy in beta thalassemia major is:

Oral deferiprone

Oral succimer

Oral desferrioxamine

Intramuscular EDTA

None

7.

In the treatment of undiagnosed megaloblastic anemia, vitamin B12 and folic acid should be given together because:

Vitamin B12 acts as a cofactor for dihydrofolate reductase

Vitamin B12 deficiency may result in methylfolate trap

Folic acid is required for conversion of methylmalonyl-CoA to succinyl CoA.

Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues

None

8.

Which of the following is given to treat thrombocytopenia secondary to anti-cancer therapy and is known to stimulate progenitor megakaryocytes?

Iron dextran

Erythropoietin

Filgrastim

Oprelvekin

None

9.

Rate of iron uptake is regulated by which one of the following:

Preparation administered

Route of administration

Age of the patient

Mucosal cell iron stores

None

10.

Erythropoietin is mainly produced in:

Kidney

Liver

Intestine

Bone

None

11.

Which of the following is true regarding iron replacement therapy in iron deficiency anemia?

Because of adverse effects of oral iron, parenteral iron is the preferred treatment

Before giving parenteral iron, the dose should be diluted and checked for anaphylaxis

Oral iron should be given till hematocrit normalizes and discontinued later because of gastric adverse effects

There is 50 percent absorption from 325 mg of ferrous sulphate by oral route

None

12.

Pre-conceptional intake of which of the following results in decrease in incidence of neural tube defects?

Vitamin A

Folate

Vitamin E

Vitamin C

None

13.

Which of the following statements about erythropoietin is FALSE?

It results in decrease in reticulocyte count

It decreases the requirement of blood transfusions

It is used for the treatment of anemia due to chronic renal failure

It can cause hypertension

None

1 out of 13

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Please note: These MCQs are intended as a general overview of Hematinics and Iron Chelators and are not a comprehensive assessment of the subject.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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