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Pharmacology Mentor > Hematinics and Iron Chelators

Hematinics and Iron Chelators

Last updated: 2024/04/15 at 6:46 PM

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Quiz on Hematinics and Iron Chelators:

1.

Which of the following is given to treat thrombocytopenia secondary to anti-cancer therapy and is known to stimulate progenitor megakaryocytes?

Filgrastim

Iron dextran

Oprelvekin

Erythropoietin

None

2.

Filgrastim is used for the treatment of:

Neutrophilia

Anemia

Neutropenia

Polycythemia

None

3.

Erythropoietin is mainly produced in:

Liver

Bone

Intestine

Kidney

None

4.

Filgrastim is a:

GM-CSF

G-CSF

GnRH analogue

T-cell stimulating factor

None

5.

All of the following are characteristic features of treatment of iron deficiency anemia with oral iron supplements, EXCEPT:

The proportion of iron absorbed reduces as hemoglobin improves

If 200-300 mg elemental iron is consumed, about 50 mg is absorbed

The treatment should be discontinued immediately once hemoglobin normalizes to prevent side effects of iron

The reticulocyte count should begin to increase in two weeks and peak in 4 weeks—this suggests good response to treatment

None

6.

Iron is most commonly absorbed from:

Lower jejunum

Stomach

Duodenum and upper jejunum

Ileum

None

7.

The most appropriate drug used for chelation therapy in beta thalassemia major is:

Oral succimer

Oral desferrioxamine

Oral deferiprone

Intramuscular EDTA

None

8.

What is the formula for parenteral iron therapy:

1.1 × body weight (kg) × Hb deficit (g/dl)

3.3 × body weight (kg) × Hb deficit (g/dl)

2.2 × body weight (kg) × Hb deficit (g/dl)

4.4 × body weight (kg) × Hb deficit (g/dl)

None

9.

Pre-conceptional intake of which of the following results in decrease in incidence of neural tube defects?

Vitamin A

Vitamin C

Vitamin E

Folate

None

10.

Rate of iron uptake is regulated by which one of the following:

Preparation administered

Mucosal cell iron stores

Age of the patient

Route of administration

None

11.

Which of the following is true regarding iron replacement therapy in iron deficiency anemia?

Because of adverse effects of oral iron, parenteral iron is the preferred treatment

There is 50 percent absorption from 325 mg of ferrous sulphate by oral route

Before giving parenteral iron, the dose should be diluted and checked for anaphylaxis

Oral iron should be given till hematocrit normalizes and discontinued later because of gastric adverse effects

None

12.

Which of the following statements about erythropoietin is FALSE?

It is used for the treatment of anemia due to chronic renal failure

It can cause hypertension

It decreases the requirement of blood transfusions

It results in decrease in reticulocyte count

None

13.

In the treatment of undiagnosed megaloblastic anemia, vitamin B12 and folic acid should be given together because:

Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues

Vitamin B12 deficiency may result in methylfolate trap

Folic acid is required for conversion of methylmalonyl-CoA to succinyl CoA.

Vitamin B12 acts as a cofactor for dihydrofolate reductase

None

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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