Drugs acting on CNS – All CNS topics EXCEPT NSAIDs Last updated: 2024/04/15 at 6:45 PM Pharmacology Mentor 148 Views Share 0 Min Read SHARE Welcome to your Drugs acting on CNS - All CNS topics EXCEPT NSAIDs Drug used for cessation of smoking are all EXCEPT: Varenecilline Buspirone Bupropion Nicotine None The drug of choice to control convulsions in eclampsia is: Phenytoin Diazepam Magnesium sulphate Pethidine None The effect of thiopentone on the CNS is quickly terminated because of: Quick first-pass elimination Redistribution Rapid metabolism in the CNS Rapid metabolism in systemic circulation None One of the following is not true about melatonin: Induces sleep Is secreted by pituitary Used in treatment of jet lag syndrome Is a pineal hormone None An epileptic adult man is on levetiracetam 1 g twice a day therapy. He is seizure free for 2 years. Now, he started developing irritability, aggression and liability of mood that is affecting his daily life. What should the doctor do? Taper the drug over 6 months Stop the drug and start another antiepileptic Decrease the dose of levetiracetam Continue the medication for another 3 years None What is the drug of choice for Obsessive Compulsive Disorder? Imipramine Fluoxetine Alprazolam Benzodiazepines None Drug of choice for prophylaxis of mania is: Clozapine Carbamazepine Lithium Haloperidol None The most important feature of the following opioid analgesic is high oral parenteral activity ratio (1:2): Methadone Diacetylmorphine Oxymorphine Morphine None Which one of the following drugs is used to treat status epilepticus? Diazepam Sodium valporate Primidone Carbamazepine None Which one of the following drug is contraindicated in acute myocardial infarction: Pentazocine Nitroglycerin Morphine Beta blockers None A patient with ruptured spleen is taken for laparotomy. His blood pressure is 80/50 and heart rate is 125/min. Induction agent of choice for this patient is: Fentanyl Ketamine Halothane Sodium Thiopentone None Opium is a derivative of: Nicotiana tobacum Papaver somniferum Solanum tuberosum Datura stromonium None Which of the following drugs is contra-indicated in acute intermittent porphyria? Midazolam Etomidate Thiopentone Propofol None Rave drug is? Amphetamine Cannabis Cocaine Heroin None Drug of choice for Trigeminal neuralgia is: Valproic acid Phenobabitone Carbamazepine Phenytoin None Local anaesthetic used as an antiarrhythmic agent is: Cocaine Lignocaine Bupivacaine Chlorprocaine None Which of the following is 100 times more potent than morphine? Fentanyl Meperidine Pentazocin Pethidine None A patient of Parkinsonism is managed with levodopa. If Vitamin B complex is administered concurrently to the patient: Decreased efficacy will result Side effects will be ameliorated The action of levodopa in brain will be potentiated Decarboxylation of l-dopa in brain will be decreased None Inverse agonist of benzodiazepine receptor is: Beta carboline Gabapentin Phenobarbitone Flumazenil None A young man is with known heroin addiction is brought in the emergency in unconscious state. On examination, the patient has decreased bowel sounds, depressed respiration and pin point pupil. The treatment of choice for this patient is: IV naloxone Oral natrexone Oral diazepam Oral Buprenorphine None A female presents with placenta previa with active bleeding and blood pressure of 80/50 mm Hg and pulse rate of 140 bpm. The choice of anaesthesia for emergency cesarean section in this female is? Spinal anaesthesia General anaesthesia with intravenous propofol Epidural anaesthesia General anaesthesia with intravenous ketamine None Dissociative anesthesia is seen on administration of: Ketamine Halothane Ether Enflurane None From which of the following routes, absorption of local anaesthetic is maximum? Caudal Brachial Intercostal Epidural None Lithium is used in a pregnant woman. Which of the following congenital anomaly occurs in the fetus? Bicuspid atresia Ebstein’s anomaly Pulmonary stenosis Tetralogy of Fallot None Which of the following drugs is used worldwide for the maintenance therapy of opioid dependence? Methadone Pethidine Naltrexone L-NAME None Methemoglobinemia is caused by: Prilocaine Bupivacaine Procaine Ropivacaine None A patient presented with vomiting and ataxia. There were oxalate crystals in the urine. The patient was given ethanol and 4 methyl pyrazole for treatment. The likely diagnosis of the patient was? Methanol poisoning Diazepam poisoning Ethanol poisoning Ethylene glycol poisoning None A person taking tricyclic antidepressants presents with blurred vision and dry mouth. These adverse effects result due to blockade of: GABAA receptors M3 muscarinic receptors H1 histamine receptors 5HT2 receptors None Antidote of methyl alcohol poisoning is: Phenytoin Fomepizole Lamotrigne Barbiturate None Nitrous oxide is contraindicated in patients with pneumothorax, pneumopericardium or intestinal obstruction, because it: Depresses an already compromised myocardium Is less soluble than nitrogen Causes the expansion of air filled body cavities Permits the use of limited FIO2 only None The specific antidote for benzodiazepine poisoning is: Flumazenil Naloxone Fomepizole Pralidoxime None Both barbiturates and salicylates are maximally absorbed in stomach because: They are highly acidic and are highly ionised in stomach They are highly basic and so less isonized in stomach They are weakly acidic and do not ionise in stomach They are weakly basic and so highly ionised in stomach None A 30 year old female, married since one year, presents to the psychiatry clinic with hyperactivity since 2 weeks. A diagnosis of mania is made. She had 3 prior episodes of mania in last 5 years and every time after taking medication she goes to premorbid state. Her urine pregnancy test is positive. Which is the preferred drug for management of this patient? Clonazepam Lithium Promethazine Haloperidol None In treatment of Parkinsonism, L-Dopa is combined with carbidopa mainly: To decrease effectiveness of L-Dopa To increase crossing of L-Dopa through BBB To decrease the treatment duration To decrease central side effects of L-Dopa None Which of the following has least extrapyramidal side effect: Haloperidol Flupenthioxol Fluphenazine Clozapine None Which of the following compounds acts as a benzodiazepine antagonist? Furazolidone Flumazenil Naloxone Naltrexone None A newborn developed respiratory depression in a postoperative ward. It can result from the use of? Heparin Propofol Opioid Furosemide None True statement regarding Bupivacaine is: Contraindicated in pregnancy Used intravenously along with lignocaine More cardiotoxic than lignocaine None A 65 years old male presented to a hospital with focal seizures. His renal function was normal. Which of the following is the drug of choice for this patient? Levetiracetam Pregbalin Valporate Oxcarbazepine None An addict presents with increased sweating, lacrimation, diarrhea, yawning and rhinorrhea. These symptoms may occur due to withdrawal of: Heroin Cannabis Alcohol Cocaine None Tolerance develops to all of the following actions of opioids except: Nausea and vomiting Analgesia Euphoria Miosis None Which of the following drug should not be given along with levodopa: Vitamin B complex MAO inhibitors Carbidopa Benserazide None A person consumes large quantities of alcohol daily since 20 years. He is physically dependent on alcohol. Drug that should not be given to this person is: Acamprosate Naltrexone Chlordiazepoxide Disulfiram None A 30-year old epileptic female, Kamla on phenytoin therapy, developed weakness and fatigue. Blood examination revealed Hb = 4.6 gm. MCV = 102 fl and MCH = 40 pg/dl. What is the most probable diagnosis? Iron deficiency anemia Heart failure Megaloblastic anemia Phenytoin induced agranulocytosis None A 32-year-old male is a known hypertensive and is being planned for cholecystectomy. Which of the following anaesthetic agents is contraindicated in this person? Etomidate Propofol Ketamine Midazolam None The disulfiram alcohol reaction occurs due to inhibition of which enzyme: Aldehyde dehydrogenase Aldehyde reductase Alcohol dehydrogenase Alcohol reductase None All of the following are CNS stimulants except: Benzodiazepines Amphetamines Cocaine Methylphenidate None Opioid analgesic used in treatment of cough is? Codeine Meperidine Loperamide Diphenoxylate None Buprenorphine is: Partial agonist at mu Receptor Full Agonist at mu Receptor Full Agonist at k receptor Partial agonist at k Receptor None Shortest acting benzodiazepine is: Alprazolam Lorazepam Midazolam Diazepam None Neural tube defect is an adverse effect of: Valproate Diazoxide Phenytoin Carbamazepine None Which of the following abolishes the therapeutic effect of levodopa? Pyridoxine Thiamine Benzerazide Carbidopa None Drug of choice in drug induced parkinsonism is: Benzhexol Amantidine Carbidopa Levodopa None Which of the following is least narcotic opioid? Codeine Papaverine Morphine Heroin None A patient presented with pain in the right lower quadrant of abdomen. He has history of renal stones in right kidney. He was prescribed an opioid which is agonist at kappa receptors and antagonist at mu receptors. The likely drug given was: Tramadol Buprenorphine Pentazocine Fentanyl None A female in labor ward was administered opioid analgesic. Which of the following drugs should be kept ready for emergency? Fentanyl Lignocaine Naloxone Diphenhydramine None In which of the following disorders, administration of barbiturates is contraindicated? Acute intermittent porphyria Kernicterus Refractory status epilepticus Anxiety disorders None A patient of schizophrenia was started on haloperidol 5 mg. Next day, he presented with uprolling of eyes. Complete neurological examination revealed no spasticity or any other abnormality. Visual acuity and opthalmoscopic findings are normal. Most likely diagnosis is: Tardive dyskinesia Akathisia Seizure Acute dystonia None Fetal hydantoin syndrome is seen if following drug is used in pregnancy? Alcohol Phenytoin Ethosuximide Phenobarbitone None In alcohol withdrawal, drug of choice is: Chlormethazole Buspirone Chlordiazepoxide TFP None Granulocytopenia, gingival hyperplasia and facial hirsutism are all possible side effects of one of the following anticonvulsant drugs? Carbamazepine Phenobarbitone Valproate Phenytoin None Disulfiram like reaction is not seen with: Cefoperazone Disulfiram Metronidazole Amoxicillin None Profound analgesia is produced by which parenteral anesthetic? Etomidate Ketamine Thiopental Propofol None Which of the following agents enhances the bioavailability of levodopa in patients with Parkinson’s disease: Selegiline Entacapone Ropinirole Amantadine None Which is a treatment of juvenile myoclonic epilepsy in pregnancy? Levetiracetam Carbamazepine Vigabatrin Phenytoin None The drug of choice in treatment of infantile spasms is: Phenobarbitone Phenytoin ACTH/vigabatrin Carbamazepine None Peripheral vasospasm is observed with which of the following anti- Parkinsonian drugs? Levodopa Bromocriptine Entacapone Ropinirole None Which of the following intravenous anesthetic agents is contraindicated in epileptic patients posted for general anesthesia? Ketamine Propofol Midazolam Thiopentone None Drug used in day care anaesthesia is: Propofol Enflurane Xenon Thiopentone None A patient of depression is stabilized on selective serotonin reuptake inhibitor (SSRI). This group of drugs produced withdrawal symptoms when stopped. Which of the following drugs has minimum risk of causing drug discontinuation symptoms? Fluvoxamine Sertraline Fluoxetine Paroxetine None A 5 years old child is suffering from cyanotic heart disease. He is planned for corrective surgery. The induction agent of choice would be: Midazolam Thiopentone Ketamine Halothane None Which one of the following drug is used in Alzheimer’s disease? Methylphenidate Doxapram Pemoline Donepezil None Which of the following local anaesthetics belongs to the ester group? Mepivacaine Procaine Lignocaine Bupivacaine None Which of the following does not have analgesic action: Morphine Ketamine Ether Halothane None Characterstic features of opioid withdrawal is: Transient visual, tactile or auditory hallucinations Seizures Delirium Tremors Rhinorrhea and lacrimation None Which among the following drug is contra-indicated in renal failure? Pethidine Atracurium Fentanyl Morphine None Time's upTime is Up! Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition. 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