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Pharmacology Mentor > Antimicrobial Chemotherapy – Antiviral and antifungal drugs

Antimicrobial Chemotherapy – Antiviral and antifungal drugs

Last updated: 2023/10/21 at 11:55 AM

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Quiz on Antimicrobial Chemotherapy - Antiviral and antifungal drugs:

Mechanism of action of oseltamivir is:

Block DNA dependent RNA polymerase

Blocks M2 protein

Apoptosis of respiratory epithelial cells

Neuraminidase inhibitor

None

Drug causing maximum peripheral neuropathy is:

Lamivudine

Didanosine

Zidovudine

Stavudine

None

Treatment of choice for coccidiodomycosis is:

Amphotericin

Flucytosine

Griseofulvin

Fluconazole

None

Which drug would treat both dermatophytosis and candidal infections?

Nystatin

Ketoconazole

Tolnaftate

Griseofulvin

None

Pancreatitis is a common complication of which one of the following:

Didanosine

Zalcitabine

Stavudine

Zidovudine

None

All of the following are common adverse effects of HAART therapy except:

Optic neuritis

Increased cholesterol

Lipodytrophy

Steatosis

None

Which of the following has poorest oral bioavailability?

Rimantidine

Amantadine

Zanamivir

Oseltamivir

None

Drug of choice in herpes simplex encephalitis is:

Vidarabine

Acyclovir

Amantadine

Interferon

None

Enfuvirtide belongs to the class of:

Protease inhibitors

Gp 120 inhibitors

Fusion inhibitors

Nucleotide reverse transcriptase inhibitors

None

10.

Liposomal amphotericin B has the following advantage over conventional amphotericin B:

Absence of infusional toxicity

Lesser nephrotoxicity

Once a week administration

Lesser cost

None

11.

Which of the following is oral drug for treatment of hepatitis C?

Peg-interferon

Ribamivir

Ledipasvir

Lamivudine

None

12.

The drug used to treat acyclovir resistant Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV) infection is:

Abacavir

Foscarnet

Valacyclovir

Ganciclovir

None

13.

Which of the following drugs is used to prevent HIV transmission from an HIV positive pregnant mother to child? (AIIMS Nov. 2011)

Stavudine

Nevirapine

Didanosine

Lamivudine

None

14.

A person is being treated for Human Immunodeficiency Virus-1. He developed hypertriglyceridemia and hypercholesterolemia. Most likely drug implicated for these adverse effects is:

Raltegravir

Ritonavir

Didanosine

Efavirenz

None

15.

Drug of choice for herpes simplex virus infection is:

Indinavir

Acyclovir

Ribavarin

Zidovudine

None

16.

A diabetic patient presents with fungal infection of sinuses and peri-orbital region with significant visual impairment. The best drug for treatment of this patient is:

Ketoconazole

Itraconazole

Amphotericin B

Broad spectrum antibiotics

None

17.

Drugs that can be used to treat candida infection are all EXCEPT:

Amphotericin

Griseofulvin

Ketoconazole

Nystatin

None

18.

Which of the following anti-metabolites act as an antifungal agent?

Decarbazine

Chlorambucil

Paclitaxel

5-Flucytosine (5 FC)

None

19.

Drug of choice for acyclovir resistant herpes is:

Foscarnet

Cidofovir

Valacyclovir

Gancyclovir

None

20.

Drug of choice for herpes simplex keratitis is:

Acyclovir

Amantadine

Interferon

Ganciclovir

None

21.

The minimum period required for post-exposure chemoprophylaxis for HIV is:

6 weeks

8 weeks

4 weeks

12 weeks

None

22.

Mechanism of action of terbinafine is?

Inhition of microtubule formation

Prevents formation of purine

Binds to ergosterol

Inhibition of ergosterol synthesis

None

23.

Drug of choice for chronic hepatitis –B is:

Zidovudine

Lamivudine

Ribavirin

IFN-alpha

None

24.

Mechanism of action of protease inhibitors is:

Causes apoptosis of the affected cells

Prevents translation of viral RNA

Inhibits proviral RNA synthesis

Prevents maturation of new viral particles

None

25.

Which of the following is most common side effect of zidovudine?

Peripheral neuropathy

Anemia

Lactic acidosis

None

26.

Amphotericin B toxicity can be reduced by?

Combining with fluconazole

Incorporating it in liposomal complex

Combining with flucytosine

Injecting the drug with dextrose

None

27.

The antimicrobial agent which inhibits the ergosterol biosynthesis is:

Griseofulvin

Fluconazole

Amphotericin B

5-Flucytosine

None

28.

Following drugs act against HIV-2 except:

Ritonavir

Zalcitabine

Efavirenz

Tenofovir

None

1 out of 28

Feel free to ask questions and provide any feedback/suggestions by filling in the comment box below.

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Please note: These MCQs are intended as a general overview of Antimicrobial Chemotherapy - Antiviral Drugs & Antifungal Drugs and are not a comprehensive assessment of the subject.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always seek the advice of a healthcare provider with any questions regarding a medical condition.

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