Parkinsons disease

Which of the following drugs is a prescription patch delivering continuous dopaminergic stimulation for Parkinson’s disease? *

Pramipexole Selegiline Levodopa Rotigotine Apomorphine

Which of the following statements best describes the mechanism of action of amantadine in Parkinson’s disease? *

Monoamine oxidase B inhibitor Anticholinergic that blocks muscarinic receptors NMDA receptor antagonist reducing glutamate excitotoxicity Dopamine agonist at D2 receptors COMT inhibitor

Which drug is a non‑dopaminergic anticholinergic that helps with tremor but is not recommended for patients over 70 due to cognitive side effects? *

Amantadine Procyclidine Benztropine Trihexyphenidyl Selegiline

A Parkinson’s patient on levodopa/carbidopa begins to experience “wear‑off” symptoms 3–4 h after dosing. Which of the following strategies would most directly address this issue? *

Add a dopamine agonist Increase levodopa dose by 25 mg Add a COMT inhibitor Add a MAO‑B inhibitor Switch to a higher‑dose levodopa formulation

What is the primary pharmacologic advantage of combining levodopa with carbidopa? *

Enhances renal excretion of levodopa Blocks dopamine D2 receptors in the periphery Delays onset of dyskinesia Reduces peripheral conversion of levodopa to dopamine Increases central dopamine synthesis

Which of the following is the most common side effect of levodopa/carbidopa therapy? *

Pulmonary fibrosis Hyperglycemia Hyponatremia Dyskinesias Constipation

A patient with Parkinson’s disease is prescribed selegiline. Which of the following is a potential drug‑interaction risk? *

Warfarin increasing bleeding risk Antihypertensives causing orthostatic hypotension Beta‑blockers causing bradycardia Calcium channel blockers causing arrhythmias SSRIs leading to serotonin syndrome

Which of the following agents is an irreversible inhibitor of monoamine oxidase B (MAO‑B) and is used as monotherapy in early Parkinson’s disease? *

L-Dopa Rasagiline Rotigotine Amantadine Selegiline

Which of the following is the most commonly used medication for the first‑line treatment of motor symptoms in early Parkinson’s disease? *

Levodopa/carbidopa Selegiline Benztropine Pramipexole Amantadine

In which clinical scenario is a dopamine agonist preferred over levodopa as first‑line therapy? *

A patient with cognitive impairment A patient under 65 with mild motor symptoms A patient with long‑standing Parkinson’s disease A patient with severe constipation A patient with advanced dyskinesia

A patient with Parkinson’s disease is experiencing increasing motor fluctuations. Which medication can be added to levodopa to prolong its effect? *

Ropinirole Entacapone Selegiline Trihexyphenidyl Ropinirole

A 68‑year‑old patient with Parkinson’s disease develops sudden onset of nausea, vomiting, and abdominal pain after increasing his levodopa dose. What is the most likely explanation? *

Levodopa‑induced gastric emptying delay Levodopa‑induced orthostatic hypotension Levodopa‑induced dyskinesia Levodopa‑induced serotonin syndrome Levodopa‑induced peripheral neuropathy

Which of the following best explains why ropinirole can cause orthostatic hypotension? *

It reduces circulating catecholamines It blocks alpha‑1 adrenergic receptors It increases central dopamine turnover It stimulates dopamine D2 receptors in the hypothalamus It increases norepinephrine reuptake

A 55‑year‑old Parkinson’s patient is on levodopa/carbidopa and is prescribed a new medication for depression. Which class of antidepressants is safest to combine with levodopa? *

Serotonin‑norepinephrine reuptake inhibitors (SNRIs) Selective serotonin reuptake inhibitors (SSRIs) Norepinephrine‑dopamine reuptake inhibitors (NDRIs) Monoamine oxidase inhibitors Tricyclic antidepressants

Which dopamine agonist is most strongly associated with impulse‑control disorders such as pathological gambling? *

Pergolide Bromocriptine Apomorphine Rotigotine Pramipexole

🎓 Practice Quiz

Your Information

Pharmacology Tools

Medical Tools