Parasympathomimetics

Which enzyme is primarily responsible for the rapid hydrolysis and inactivation of acetylcholine in the synaptic cleft? *

Cevimeline is a direct-acting cholinergic agonist used to treat dry mouth (xerostomia) associated with Sjögren\'s syndrome. It exhibits selectivity for which receptor subtype? *

Indirect-acting cholinergic agonists (Cholinesterase inhibitors) increase the concentration of which neurotransmitter at the receptor sites? *

Drugs classified as direct-acting cholinergic agonists primarily exert their effects by mimicking which endogenous substance? *

A major side effect of excessive parasympathomimetic stimulation (\"SLUDGE\" syndrome) includes which of the following? *

Which drug is a non-selective, centrally acting, reversible cholinesterase inhibitor that can cross the blood-brain barrier? *

Pilocarpine is a common direct-acting cholinergic agonist. Its primary clinical use is the treatment of which condition? *

Why are organophosphate poisonings treated with both atropine (an antagonist) and pralidoxime (a reactivator)? *

A major difference between direct-acting agonists (like Bethanechol) and indirect-acting agonists (like Neostigmine) is: *

Stimulation of M2 receptors in the heart primarily results in which effect? *

Which drug is a reversible cholinesterase inhibitor used to treat the symptoms of Myasthenia Gravis? *

Which statement accurately describes the effect of a cholinesterase inhibitor on the neuromuscular junction (NMJ)? *

Nicotinic receptors (Nn) found at the autonomic ganglia are primarily responsible for which physiological action when stimulated by cholinergic agonists? *

Which neurotransmitter is the primary agonist at muscarinic and nicotinic receptors? *

Which of the following effects is NOT typically associated with the activation of muscarinic receptors by a parasympathomimetic agent? *

Which drug is a reversible, short-acting cholinesterase inhibitor often used diagnostically for Myasthenia Gravis? *

Overdose with an organophosphate pesticide (a highly potent, irreversible AChE inhibitor) would primarily cause severe effects mediated by which receptors? *

Bethanechol is used to treat postoperative urinary retention. Which receptor type does it primarily act upon to cause bladder contraction? *