Accurate Allometric Scaling for Pre-Clinical Research.

Stop using simple weight ratios. Calculate scientifically accurate dosage conversions between humans and laboratory animals using Body Surface Area (BSA) normalization and FDA-standardized $K_m$ factors.

🐭 Human to Animal Dose Calculator

Convert doses between species using FDA-approved Km factor allometric scaling method.

🤖 AI-Powered Allometric Scaling

Convert doses between species using FDA-approved Km factors with AI recommendations for species-specific considerations.

Drug Name (optional):

Conversion Direction:

Human → Animal (Calculate AED) Animal → Human (Calculate HED)

Select Animal Species:

Human Dose (mg/kg):

Actual Animal Weight (kg) - Optional: If provided, will calculate total dose for this specific animal.

📋 Km Factor Reference Table

Based on FDA Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials

Species	Reference Weight (kg)	BSA (m²)	Km Factor
Human	60	1.62	37
Mouse	0.02	0.007	3
Rat	0.15	0.025	6
Hamster	0.08	0.016	5
Guinea Pig	0.4	0.05	8
Rabbit	1.8	0.15	12
Cat	2	0.17	11.7
Monkey (Rhesus)	3	0.25	12
Dog	10	0.5	20
Marmoset	0.35	0.06	6
Squirrel Monkey	0.6	0.09	7
Baboon	12	0.6	20
Micro Pig	20	0.74	27
Mini Pig	40	1.14	35

Pharmacology Tool – KaTeX Fix

The Science Behind the Tool

Why “mg/kg” Is Often Wrong

Small animals have faster metabolic rates than humans. Simply prescribing the same $\text{mg/kg}$ dose often leads to under-dosing in smaller species.

This tool uses the Allometric Scaling Method, the gold standard for translational medicine.

Formula: Uses the exponent $0.67$ or $0.75$ for body surface area normalization.
$K_m$ Factors: Automatically applies the correct correction factor (e.g., Human $K_m=37$, Rat $K_m=6$, Mouse $K_m=3$).
Result: A dose that reflects the true metabolic clearance of the drug in the target species.

Core Capabilities

Essential for Drug Development & Veterinary Medicine

🔄 Bidirectional Conversion

Human $\to$ Animal: Calculate the starting dose for animal studies based on human clinical data.
Animal $\to$ Human: Convert NOAEL (No Observed Adverse Effect Level) from toxicity studies into a Maximum Recommended Starting Dose (MRSD) for Phase I human trials.

🐾 Multi-Species Support

Pre-loaded with standard $K_m$ factors for:

Mouse, Rat, Guinea Pig, Hamster
Rabbit, Dog (Beagle), Cat
Monkey (Cynomolgus/Rhesus), Marmoset
Human (Adult & Child)

Understanding Human Equivalent Dose (HED)

The Role of Body Surface Area (BSA)

While body weight varies linearly, metabolic processes (like liver enzyme activity and renal clearance) correlate better with body surface area. Our animal dose calculator normalizes the dose to $\text{mg}/\text{m}^2$ rather than just $\text{mg/kg}$, ensuring that a mouse receives a proportionally higher dose per unit of weight to achieve the same systemic exposure as a human.

Allometric Scaling FAQ

Q: Why is the mouse dose so much higher in mg/kg?
A: A mouse has a much higher metabolic rate than a human. To maintain the same drug concentration in the blood, the mouse often needs a dose (in $\text{mg/kg}$) that is $12\times$ higher than the human dose.