Uroxatral Uroxatral (also known as prazosin? Wait: Actually Uroxatral is a selective α1A‑adrenergic antagonist). — Mechanism of Action Selective α1A‑adrenergic receptor blockade in the prostate and bladder neck. ↓ Intramural smooth‑muscle tone → relaxation of the prostatic urethra. ↓ Lumen resistance → increased urinary flow, decreased post‑void residual volume. Minimal activity at α1B/α1D receptors → … Read more
Urokinase Urokinase (also known as urokinase-type plasminogen activator, uPA) is a serine protease derived from human kidney cells used clinically as a potent thrombolytic agent. Mechanism of Action Direct activation of plasminogen. Urokinase binds to the plasminogen form on fibrin surfaces, converting it to plasmin, a broad‑spectrum fibrinolytic enzyme that degrades fibrin clots. Fibrin‑specific activity. … Read more
Urocit‑K Urocit‑K is a branded pharmaceutical formulation that supplies potassium chloride (KCl) and magnesium carbonate (MgCO₃). It is primarily used to tilt the body’s electrolyte balance toward normality and to counteract constipation or ileus by osmotic action. Mechanism of Action Potassium Replacement KCl is absorbed via active transcellular transport or passive diffusion in the intestinal … Read more
Uro‑MP Uro‑MP is a patented, orally‑administered formulation indicated for the treatment of calcium‑oxalate kidney stones and the prevention of urinary tract stone recurrence. The active moiety combines a potassium‑based alkalinizing agent with a competitive inhibitor of renal tubular calcium reabsorption. The drug is currently available in several countries as a prescription‑only medication and is marketed … Read more
Urispas Urispas is a topical antimuscarinic agent approved for the treatment of urge‑to‑urinate disorders, primarily overactive bladder (OAB) and urinary frequency. Its formulation is designed to provide rapid, localized symptom relief while minimizing systemic exposure. — Mechanism of Action Competitive antagonist of muscarinic M3 receptors in the detrusor smooth muscle. Inhibits acetylcholine‑mediated detrusor contraction, reducing … Read more
Uribel Ursodeoxycholic acid (manufactured as Uribel) is a synthetic bile acid used to dissolve cholesterol gallstones, treat cholestatic liver disease, and prevent gallstone recurrence. Mechanism of Action Reduces cholesterol solubility in bile by replacing toxic bile acids with the hydrophilic ursodeoxycholic acid. Inhibits cholesterol micelle formation → ↓ nucleation & aggregation of cholesterol crystals. Stimulates … Read more
Urelle Mechanism of Action Urelle is a highly selective serotonin‑reuptake inhibitor (SSRI). It binds with high affinity to the serotonin transporter (SERT), blocking re‑uptake of serotonin from the synaptic cleft and thereby increasing extracellular serotonin levels in key brain regions involved in mood regulation and anxiety. Primary target: SERT Result: Augmented serotonergic neurotransmission → antidepressant … Read more
Urecholine Urecholine (trade name Urechol®) is a novel, highly selective muscarinic receptor agonist marketed for the management of acute urinary retention and related lower‑tract dysfunction. It mimics the action of acetylcholine with preferential affinity for M3 muscarinic receptors in the bladder and gastrointestinal smooth muscle, thereby promoting detrusor contraction and improving colonic motility. Mechanism of … Read more
Urea Cream Urea cream is a topical keratolytic and humectant used primarily in dermatology to manage hyperkeratotic skin disorders. Mechanism of Action Keratolytic effect – Urea impedes the cross‑linking of filaggrin, keratin, and keratin‐desmosome complexes, enhancing desquamation. Hydration – Urea is a natural humectant that attracts and retains water by binding to phospholipids and proteins … Read more
Urea Mechanism of Action Urea is a small, naturally occurring organic compound that serves as a key denominator in several topical formulations for dermatologic conditions. Its main actions include: Hydration & Humectancy – Urea dissolves in water, attracting moisture into the stratum corneum, enhancing skin hydration. Keratolysis – At concentrations > 10 %, urea disrupts hydrogen … Read more