Apixaban Apixaban is a direct oral anticoagulant (DOAC), widely recognized as a selective, reversible Factor Xa inhibitor used in thromboprophylaxis and antithrombotic therapy. Mechanism of Action Selective inhibition of activated Factor Xa → prevents conversion of prothrombin to thrombin. Binds both free Factor Xa and clot‑bound Factor Xa, ensuring sustained anticoagulation during clot formation. Does not inhibit thrombin … Read more
Aspirin Mechanism of Action Aspirin (acetyl‑salicylic acid) irreversibly acetylates serine residues in the active sites of cyclo‑oxygenase enzymes COX‑1 and COX‑2. Inhibition of COX‑1 in platelets ↓ thromboxane A₂ → potent, long‑lasting antiplatelet effect. Inflammatory tissues: COX‑2 inhibition reduces prostaglandin‑mediated pain, fever, and swelling. Low‑dose aspirin (≤100 mg/day) primarily targets platelets; higher doses (≥300 mg) provide additional anti‑inflammatory … Read more
Nayzilam (lacosamide) Section Key Points Generic Lacosamide Brand Nayzilam (Europe, Middle East) ATC N03EL02 Drug Class Antiepileptic – selective sodium‑channel modulator Mechanism of Action Augments slow inactivation of voltage‑gated Na⁺ channels → reduces high‑frequency repetitive firing of neurons. Does not affect fast inactivation nor other ion channels [1]. Pharmacokinetics • Oral bioavailability ≈93 % (rapid absorption).• … Read more