Introduction/Overview Histamine H2 receptor antagonists represent a foundational class of therapeutic agents in gastroenterology and acid-related disorders. These drugs, commonly referred to as H2 blockers or H2RAs, competitively inhibit histamine’s action at the parietal cell H2 receptor, leading to a significant reduction in gastric acid secretion. Their development in the 1970s, culminating in the introduction … Read more
Introduction/Overview Histamine H2 receptor antagonists represent a foundational class of therapeutic agents in gastroenterology and acid-related disorders. These drugs, commonly referred to as H2 blockers or H2RAs, competitively inhibit histamine’s action at the parietal cell H2 receptor, leading to a significant reduction in gastric acid secretion. Their development in the 1970s marked a pivotal advancement … Read more
Introduction/Overview The renin-angiotensin-aldosterone system (RAAS) represents a critical hormonal cascade in the regulation of blood pressure, fluid balance, and cardiovascular homeostasis. Pharmacological antagonism of this system constitutes a cornerstone in the management of hypertension, heart failure, and chronic kidney disease. Angiotensin receptor blockers, also known as angiotensin II receptor antagonists or AT1 receptor blockers, are … Read more