Pharmacology | Pharmacology Mentor

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

January 28, 2026February 7, 2023 by Pharmacology Mentor

Non-steroidal anti-inflammatory drugs (NSAIDs) are cornerstone analgesic, antipyretic, and anti-inflammatory agents whose primary mechanism is inhibition of cyclooxygenase (COX) enzymes to reduce prostaglandin and thromboxane synthesis. A complete pharmacology chapter should cover COX biology, detailed classification, pharmacokinetics/dynamics, therapeutic uses, adverse effects, drug interactions, special populations, and evidence-based risk mitigation strategies from standard pharmacology texts and … Read more

Hematinics and iron chelators

October 13, 2025February 7, 2023 by Pharmacology Mentor

Hematinics are agents that supply essential substrates for erythropoiesis—principally iron, vitamin B12, and folate—while iron chelators remove excess iron from overload states; together, these drugs correct deficiency anemias and mitigate transfusional siderosis when used with appropriate monitoring and route selection. This chapter details classification, mechanisms, pharmacokinetics, indications, dosing, adverse effects, interactions, and evidence-based cautions for … Read more

Pharmacology of Opioid Analgesics

December 28, 2025February 5, 2023 by Pharmacology Mentor

Introduction Opioid analgesics comprise a diverse class of drugs used primarily for pain management. Derived from natural sources such as the opium poppy or synthesized in laboratories, these agents have been used for centuries for their potent analgesic and sedative properties. Opioids remain the most effective agents for controlling intense and certain chronic pain syndromes, … Read more

Sildenafil: Its Use as a PDE5 Inhibitor for Erectile Dysfunction

December 28, 2025January 30, 2023 by Pharmacology Mentor

Phosphodiesterase type 5 (PDE5) inhibitors are first‑line oral agents for erectile dysfunction that augment the endogenous nitric oxide–cGMP pathway in the corpus cavernosum to facilitate erection with sexual stimulation, and the class includes sildenafil, vardenafil, tadalafil, and avanafil. Standard pharmacology texts detail shared mechanisms with clinically important differences in onset, duration, food effects, selectivity, and … Read more

Androgens and Antiandrogens

October 6, 2025January 30, 2023 by Pharmacology Mentor

Androgens are steroid hormones that promote the development and maintenance of male sex characteristics. The principal naturally occurring androgens in humans are testosterone and dihydrotestosterone (DHT), both synthesized mainly in the testes and, to a lesser extent, the adrenal cortex. Androgens bind to intracellular androgen receptors (AR), acting as transcription factors to regulate gene expression … Read more