Introduction/Overview Selegiline, also known by its chemical name L-deprenyl, represents a cornerstone agent in the management of Parkinson’s disease and occupies a unique niche in neuropsychopharmacology. Initially developed in the 1960s, its clinical introduction marked a significant advancement in the symptomatic treatment of neurodegenerative disorders. The drug’s primary mechanism involves the selective and irreversible inhibition … Read more
1. Introduction/Overview Selegiline, also known internationally as L-deprenyl, represents a cornerstone agent in the therapeutic management of neurodegenerative and neuropsychiatric disorders. As a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), its introduction marked a significant advancement in the symptomatic treatment of Parkinson’s disease. The drug’s unique pharmacological profile, which extends beyond simple enzyme … Read more
Introduction/Overview Imipramine, recognized historically as the first tricyclic antidepressant (TCA), represents a cornerstone in the development of psychopharmacology. Its introduction in the late 1950s marked a significant departure from earlier treatments for depression and provided the first effective chemical therapy for major depressive disorder. Although newer classes of antidepressants have since been developed, imipramine remains … Read more
Introduction/Overview Duloxetine hydrochloride is a centrally-acting pharmacological agent classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). Its development marked a significant advancement in psychopharmacology and pain management, offering a dual mechanism distinct from earlier selective serotonin reuptake inhibitors (SSRIs). The clinical relevance of duloxetine is substantial, as it addresses multiple conditions through modulation of monoaminergic neurotransmission, … Read more
Introduction/Overview Venlafaxine is a bicyclic phenylethylamine derivative that functions as a potent antidepressant agent. It represents a significant class of psychotropic medications and is considered a first-line agent for the management of major depressive disorder and several anxiety disorders. The clinical introduction of venlafaxine marked a departure from the traditional tricyclic antidepressants and selective serotonin … Read more
Introduction/Overview Paroxetine represents a cornerstone psychopharmacological agent within the class of selective serotonin reuptake inhibitors (SSRIs). First introduced in the early 1990s, it has been extensively utilized in the management of a spectrum of mood and anxiety disorders. Its clinical relevance is underscored by its potent serotonergic activity and distinct pharmacokinetic profile, which includes significant … Read more
Introduction/Overview Sertraline is a psychotropic medication belonging to the class of selective serotonin reuptake inhibitors (SSRIs). It represents one of the most widely prescribed antidepressant agents globally, forming a cornerstone in the pharmacological management of mood and anxiety disorders. First approved for medical use in the United States in 1991, its introduction marked a significant … Read more
Introduction/Overview Quetiapine fumarate is an atypical antipsychotic medication with a broad receptor-binding profile, conferring efficacy across multiple psychiatric and neurological conditions. Initially developed as a successor to clozapine, it has become one of the most widely prescribed psychotropic agents globally due to its established efficacy and a generally favorable tolerability profile regarding extrapyramidal symptoms. Its … Read more
Introduction/Overview Olanzapine represents a cornerstone agent in the class of atypical antipsychotics, widely employed in the management of several psychiatric disorders. Its development marked a significant advancement over first-generation antipsychotics, primarily due to a distinct adverse effect profile characterized by a lower propensity for extrapyramidal symptoms. The clinical relevance of olanzapine is underscored by its … Read more
Introduction/Overview Risperidone represents a cornerstone agent in the class of atypical antipsychotics, also known as second-generation antipsychotics. Its development marked a significant advancement in psychopharmacology, offering an improved therapeutic profile compared to first-generation agents, particularly regarding the reduced risk of extrapyramidal symptoms at therapeutic doses. The drug is extensively utilized in the management of schizophrenia, … Read more