Category: Pharmacology
Pharmacology of Imatinib
Introduction/Overview Imatinib mesylate represents a paradigm shift in the therapeutic approach to certain malignancies, establishing the proof-of-concept for molecularly targeted cancer therapy. As a selective...
Pharmacology of Doxorubicin
Introduction/Overview Doxorubicin, a potent anthracycline antibiotic derived from Streptomyces peucetius var. caesius, represents a cornerstone of modern cytotoxic chemotherapy. Since its introduction into clinical practice...
Pharmacology of Vincristine
Introduction/Overview Vincristine, a naturally occurring alkaloid derived from the Madagascar periwinkle plant Catharanthus roseus, represents a cornerstone chemotherapeutic agent with a clinical history spanning over...
Pharmacology of Cisplatin
1. Introduction/Overview Cisplatin, or cis-diamminedichloroplatinum(II), represents a cornerstone of modern chemotherapy and a seminal discovery in oncology. Its serendipitous discovery in the 1960s, arising from...
Pharmacology of Cyclophosphamide
Introduction/Overview Cyclophosphamide represents a cornerstone agent in the therapeutic armamentarium for a diverse array of malignant and autoimmune conditions. As a nitrogen mustard alkylating agent...
Pharmacology of Metronidazole
Introduction/Overview Metronidazole represents a cornerstone antimicrobial agent within the nitroimidazole class, distinguished by its potent activity against anaerobic bacteria and protozoa. First introduced into clinical...
Pharmacology of Artemisinin
1. Introduction/Overview The discovery of artemisinin, a sesquiterpene lactone endoperoxide isolated from the plant Artemisia annua (sweet wormwood), represents one of the most significant advances...
Pharmacology of Chloroquine
Introduction/Overview Chloroquine, a 4-aminoquinoline compound, represents a cornerstone agent in the chemotherapeutic arsenal against malaria. First synthesized in 1934 and introduced into clinical practice in...
Pharmacology of Zidovudine
Introduction/Overview Zidovudine, also known as azidothymidine (AZT), represents a cornerstone in the historical and contemporary management of human immunodeficiency virus (HIV) infection. As the first...
Pharmacology of Acyclovir
Introduction/Overview Acyclovir, a synthetic purine nucleoside analogue, represents a cornerstone in the chemotherapeutic management of infections caused by herpesviruses. Its development in the late 1970s...