Introduction/Overview Domperidone is a benzimidazole derivative that functions as a selective peripheral dopamine D2 and D3 receptor antagonist. It is primarily employed as an antiemetic and gastroprokinetic agent, facilitating the management of nausea, vomiting, and symptoms associated with delayed gastric emptying. The clinical relevance of domperidone stems from its distinct pharmacological profile, particularly its limited … Read more
Introduction/Overview Sucralfate represents a distinctive therapeutic agent within the pharmacopeia for gastrointestinal disorders, functioning primarily through local, non-systemic mechanisms. As a complex salt of sucrose octasulfate and polyaluminum hydroxide, it is classified as a cytoprotective agent, offering a unique approach to managing acid-peptic disease. Its clinical relevance persists despite the widespread adoption of potent acid-suppressive … Read more
Introduction/Overview Famotidine is a competitive antagonist of histamine at the H2 receptor, belonging to the class of medications known as H2 receptor antagonists (H2RAs). Since its introduction in the 1980s, it has been a cornerstone in the management of acid-peptic disorders, offering a favorable safety profile and predictable pharmacokinetics. While the therapeutic landscape for acid … Read more
Introduction/Overview Esomeprazole represents a cornerstone agent in the pharmacological management of acid-related disorders. As the S-isomer of omeprazole, it was developed to provide enhanced efficacy and consistency in gastric acid suppression. The clinical introduction of proton pump inhibitors (PPIs) like esomeprazole marked a significant advancement over preceding therapies such as histamine H2-receptor antagonists, offering more … Read more
1. Introduction/Overview Pantoprazole is a benzimidazole derivative that functions as a potent inhibitor of gastric acid secretion. As a member of the proton pump inhibitor class, it represents a cornerstone in the management of acid-related disorders. The clinical introduction of proton pump inhibitors marked a significant advancement over preceding therapies like histamine H2-receptor antagonists, offering … Read more
1. Introduction/Overview Vitamin D, specifically in its physiologically active hormonal form, represents a critical secosteroid hormone with pleiotropic effects extending far beyond its classical role in calcium and phosphate homeostasis. The pharmacology of vitamin D encompasses a complex interplay of endogenous synthesis, exogenous supplementation, and intricate metabolic activation. Its clinical relevance is underscored by its … Read more
Introduction/Overview Calcitonin is a polypeptide hormone primarily involved in calcium and bone metabolism. Originally discovered in 1961 by Copp and Cheney, it is secreted by the parafollicular cells (C-cells) of the thyroid gland in mammals. The hormone plays a significant, though non-essential, role in calcium homeostasis, acting as a physiological antagonist to parathyroid hormone (PTH). … Read more
Introduction/Overview Calcitonin is a polypeptide hormone primarily involved in calcium and bone homeostasis. It is secreted by the parafollicular cells (C-cells) of the thyroid gland in mammals, though in non-mammalian vertebrates such as fish, reptiles, and birds, it is produced in the ultimobranchial glands. The pharmacological interest in calcitonin stems from its potent hypocalcemic and … Read more
Introduction/Overview Alendronate sodium is a nitrogen-containing bisphosphonate that represents a cornerstone in the pharmacological management of metabolic bone diseases, most notably osteoporosis. Its development and clinical introduction marked a significant advancement in the ability to prevent skeletal-related events by fundamentally altering bone turnover dynamics. The therapeutic importance of alendronate is underscored by its extensive evidence … Read more
Introduction/Overview Alendronate sodium is a nitrogen-containing bisphosphonate that represents a cornerstone in the pharmacological management of metabolic bone diseases, most notably osteoporosis. Its development and clinical adoption marked a significant advancement in the ability to reduce fracture risk by fundamentally altering bone turnover. The drug’s primary clinical relevance stems from its potent inhibition of osteoclast-mediated … Read more