Pharmacology

Introduction/Overview Rituximab represents a cornerstone in the therapeutic application of monoclonal antibody technology, marking a significant advancement in the treatment of B-cell mediated disorders. As a chimeric murine-human monoclonal antibody,…

Introduction/Overview Bleomycin represents a cornerstone chemotherapeutic agent within the class of antitumor antibiotics. Its unique mechanism of action, which involves direct DNA cleavage, distinguishes it from many other cytotoxic drugs…

Introduction/Overview Bleomycin is a cytotoxic glycopeptide antibiotic with established antineoplastic activity, primarily employed in the management of specific malignancies such as Hodgkin lymphoma, germ cell tumors, and squamous cell carcinomas.…

Introduction/Overview Paclitaxel represents a cornerstone agent in modern antineoplastic therapy, belonging to the taxane class of chemotherapeutic drugs. Originally isolated from the bark of the Pacific yew tree, Taxus brevifolia,…

Introduction/Overview 5-Fluorouracil (5-FU) represents a cornerstone of cytotoxic chemotherapy, belonging to the antimetabolite class of agents. Since its clinical introduction in the 1950s following the observation that rat hepatomas utilized…

Introduction/Overview Praziquantel is a broad-spectrum anthelmintic agent that represents a cornerstone in the chemotherapy of parasitic flatworm infections. Its development in the 1970s marked a significant therapeutic advance, providing an…

Introduction/Overview Diethylcarbamazine (DEC) is a synthetic piperazine derivative that has served as a cornerstone anthelmintic agent for over seven decades. Its primary clinical significance lies in the treatment and control…

Introduction/Overview Ivermectin represents a landmark therapeutic agent in the field of antiparasitic chemotherapy. Its discovery, originating from the soil bacterium Streptomyces avermitilis, has had a profound impact on global public…

Introduction/Overview Ivermectin represents a landmark therapeutic agent in the field of antiparasitic chemotherapy. Its discovery, originating from the soil bacterium Streptomyces avermitilis, has had a profound impact on global public…

Introduction/Overview Mebendazole represents a cornerstone agent within the benzimidazole class of anthelmintic drugs, playing a critical role in global public health initiatives against soil-transmitted helminthiases. First introduced in the early…