1. Introduction/Overview The development of targeted cancer therapies represents a paradigm shift in oncology, moving from broadly cytotoxic agents to drugs designed to interfere with specific molecular pathways that are crucial for tumor growth and survival. This approach is predicated on the identification of genetic and epigenetic alterations that drive oncogenesis, a concept often termed … Read more
1. Introduction/Overview The development of targeted cancer therapies represents a paradigm shift in oncology, moving from broadly cytotoxic chemotherapeutic agents to drugs designed to interfere with specific molecular pathways that drive tumorigenesis and cancer progression. This approach is predicated on the identification of genetic and epigenetic alterations that confer a survival advantage to malignant cells. … Read more
Introduction/Overview The pharmacological management of malignant disease represents a cornerstone of modern oncology. Cytotoxic chemotherapy, despite the advent of targeted therapies and immunotherapies, remains a fundamental treatment modality for a wide spectrum of cancers. These agents are characterized by their capacity to kill rapidly dividing cells, a property that underlies both their therapeutic efficacy against … Read more