1. Introduction Skin cancer represents the most common malignancy in many populations, with its incidence continuing to rise globally. The term encompasses a heterogeneous group of neoplasms arising from the skin’s cellular components, primarily the epidermis. The three principal typesโmelanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC)โdiffer fundamentally in their cells of … Read more
1. Introduction Testicular cancer represents a malignancy originating in the testis, most commonly from germ cells. It is a model of success in modern oncology due to its high cure rates, which exceed 95% across all stages, largely attributable to the development of effective cisplatin-based chemotherapy regimens. This malignancy primarily affects young and middle-aged men, … Read more
1. Introduction Gynecologic malignancies represent a significant proportion of cancer morbidity and mortality worldwide, with ovarian and uterine cancers being among the most prevalent. Ovarian cancer, though less common than other gynecologic cancers, is associated with the highest mortality rate, largely due to its frequent diagnosis at an advanced stage. Uterine cancer, predominantly endometrial carcinoma, … Read more
1. Introduction Cervical cancer represents a significant global health burden, with persistent infection by high-risk human papillomavirus (HPV) identified as the necessary causative agent in virtually all cases. The establishment of organized screening programs, historically based on cytology, has led to a marked reduction in cervical cancer incidence and mortality in developed nations. The integration … Read more
1. Introduction Sexually transmitted infections represent a significant global public health burden, with Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum being among the most prevalent bacterial pathogens. These infections are characterized by their transmission primarily through sexual contact and their potential to cause severe long-term sequelae if left untreated, including pelvic inflammatory disease, infertility, ectopic … Read more
1. Introduction The lower urinary tract, with the urinary bladder as its principal reservoir, is integral to the maintenance of continence and the controlled elimination of waste. Disorders of bladder function and structure represent a significant source of morbidity, impacting quality of life and, in the case of malignancy, mortality. Two clinically paramount and pharmacologically … Read more
1. Introduction Anorectal disorders represent a prevalent group of conditions affecting the terminal portion of the gastrointestinal tract, often associated with significant morbidity, reduced quality of life, and considerable healthcare expenditure. These disorders, while rarely life-threatening, impose a substantial burden due to their high incidence and the discomfort they cause. The clinical management of these … Read more
1. Introduction Diverticular disease represents a spectrum of conditions associated with the presence of diverticula, which are sac-like protrusions of the colonic mucosa and submucosa through the muscularis propria. The condition manifests primarily in two forms: the largely asymptomatic presence of diverticula, termed diverticulosis, and the inflammatory or infectious complication of these structures, known as … Read more
1. Introduction Inflammatory bowel disease (IBD) represents a group of chronic, relapsing-remitting inflammatory disorders of the gastrointestinal tract, with Crohn’s disease (CD) and ulcerative colitis (UC) constituting the two principal idiopathic forms. These conditions are characterized by a dysregulated immune response to environmental triggers in genetically susceptible individuals, leading to persistent mucosal inflammation. The distinction … Read more
1. Introduction Cirrhosis represents the histological endpoint of progressive, chronic liver disease, characterized by the irreversible replacement of normal hepatic parenchyma with diffuse fibrosis and regenerative nodules. This architectural distortion leads to the cardinal clinical consequences of hepatic insufficiency and portal hypertension. The condition constitutes a major global health burden, ranking as a leading cause … Read more