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Antiarrhythmic drugs: Mexiletine (Class 1B)

Mexiletine is an oral Class IB antiarrhythmic and sodium channel blocker structurally related to lidocaine, used primarily for ventricular arrhythmias and selected channelopathies such as LQT3 where late sodium current…

Pharmacology Mentor September 17, 2023

CVS Pharmacology

Antiarrhythmic drugs: Lidocaine (Class 1B)

If you trained in a time when every crash cart seemed to include “lido,” you remember lidocaine as the go-to antidote for ugly ventricular ectopy. Today, it has a more…

Pharmacology Mentor September 17, 2023

CVS Pharmacology

Antiarrhythmic drugs: Disopyramide (Class 1A)

Introduction Disopyramide is a Class 1a antiarrhythmic agent, primarily used in the treatment of ventricular tachycardia. It functions as a sodium channel blocker, inhibiting conduction by depressing the increase in…

Pharmacology Mentor September 17, 2023

CVS Pharmacology

Antiarrhythmic drugs: Quinidine (Class 1A)

Overview and Learning Objectives By the end of this chapter, you should be able to: Describe the chemical origin, classification, and electrophysiologic actions of quinidine. Explain its pharmacokinetics, pharmacodynamics, and…

Pharmacology Mentor September 17, 2023

CVS Pharmacology

Antiarrhythmic drugs: Procainamide (Class 1A)

Procainamide is a Class IA antiarrhythmic that blocks fast INaINa channels and prolongs repolarization via its active metabolite N-acetylprocainamide (NAPA), making it useful for acute management of a variety of ventricular and…

Pharmacology Mentor September 17, 2023

ANS Pharmacology

Classification of Adrenergic Receptors: A Quick Overview

Introduction Adrenergic receptors play a pivotal role in regulating physiological processes and are the target of numerous pharmacological interventions. These receptors are broadly classified into α and β types, with…

Pharmacology Mentor September 9, 2023

General Pharmacology

Adverse Drug Reactions: On-target and Off-target aspect

Introduction Adverse drug reactions (ADRs) remain a formidable challenge in clinical pharmacology and patient care. They can significantly diminish quality of life, induce severe morbidity and mortality, extend hospital stays,…

Pharmacology Mentor September 9, 2023

General Pharmacology

The History of Pharmacology

The Intersection of Religion and Medicine At the dawn of human civilization, religion and medicine were inextricably linked. Priests, shamans, and holy people were the original pharmacologists, wielding the power…

Pharmacology Mentor September 8, 2023

General Pharmacology

Pharmacokinetic Principles: A Comprehensive Guide

Introduction Pharmacokinetics is the science that describes how drugs move within the body and is crucial for rational dosing in clinical settings. This article aims to provide a comprehensive understanding…

Pharmacology Mentor September 6, 2023

General Pharmacology

Navigating the Complex Landscape of Drug Targets: From Validation to Druggability

Introduction The journey from drug discovery to market is a complex and intricate process, often fraught with challenges and uncertainties. One of the most critical aspects of this journey is…

Pharmacology Mentor September 6, 2023

Antiarrhythmic drugs: Mexiletine (Class 1B)

Antiarrhythmic drugs: Lidocaine (Class 1B)

Antiarrhythmic drugs: Disopyramide (Class 1A)

Antiarrhythmic drugs: Quinidine (Class 1A)

Antiarrhythmic drugs: Procainamide (Class 1A)

Classification of Adrenergic Receptors: A Quick Overview

Adverse Drug Reactions: On-target and Off-target aspect

The History of Pharmacology

Pharmacokinetic Principles: A Comprehensive Guide

Navigating the Complex Landscape of Drug Targets: From Validation to Druggability

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