Atropine ✓ Passing Score: 50% 📝 Questions: 20 🎓 Practice Quiz Welcome! This is a practice quiz to test your knowledge. Please enter your details below to participate. Your results will be emailed to you upon completion. Your Information Name * Email * Start Quiz → Question 1 of 20 1 The effect of atropine on the sweat glands (leading to reduced sweating) is mediated by blocking which muscarinic receptor subtype? * M2 M5 M4 M1 M3 2 Which adverse effect is most likely to occur with systemic administration of therapeutic doses of atropine due to its action on the CNS? * Profound sedation and hypnosis Peripheral neuropathy Mild restlessness, confusion, or drowsiness Euphoria and respiratory depression Tremors and seizures 3 Atropine has a relatively low affinity for which type of receptor compared to its affinity for muscarinic receptors? * Alpha-adrenergic receptors Nicotinic receptors Muscarinic M2 receptors Beta-adrenergic receptors Muscarinic M3 receptors 4 Atropine causes mydriasis (pupil dilation) primarily by antagonizing the action of acetylcholine on which type of receptor in the iris? * Alpha-1 adrenergic receptors Muscarinic M1 receptors Muscarinic M3 receptors Beta-2 adrenergic receptors Nicotinic receptors 5 Atropine\\\'s duration of action is generally considered: * Intermediate (4-10 hours) Short (1-2 hours) Dependent entirely on plasma concentration Long (24 hours or more) Very short (minutes) 6 Compared to pilocarpine (a muscarinic agonist), atropine exhibits which characteristic? * Lower receptor affinity Higher intrinsic activity Non-reversible binding Greater selectivity for nicotinic receptors Competitive antagonism 7 Which of the following effects is *most* characteristic of therapeutic doses of atropine? * Miosis (pupil constriction) Tachycardia Bronchoconstriction Decreased heart rate Increased salivation 8 Atropine is minimally effective, if at all, in blocking which receptor type at standard therapeutic doses? * Muscarinic M1 Muscarinic M3 Muscarinic M2 Nicotinic N2 (Ganglia) Nicotinic N1 (Skeletal Muscle) 9 Which drug is structurally related to atropine and is often preferred in pediatric anesthesia due to a shorter duration of action? * Benztropine Glycopyrrolate Homatropine Scopolamine Tropicamide 10 Which formulation of atropine is most effective for reversing bradycardia in an emergency setting? * Subcutaneous infusion Oral tablets Transdermal patch Intravenous injection Intramuscular injection 11 Atropine is commonly used clinically prior to anesthesia to: * Increase gastric acid secretion Reduce the risk of postoperative nausea and vomiting Reverse neuromuscular blockade Induce profound sedation Prevent bradycardia caused by cholinergic stimulation 12 Atropine is contraindicated in patients with which pre-existing condition due to the risk of exacerbation? * Hyperthyroidism Hypertension Hypothyroidism Acute angle-closure glaucoma Bradycardia 13 What is the primary clinical effect of atropine when used ophthalmologically (eye drops)? * Miosis (pupil constriction) Increased tear production Reduced aqueous humor production Cycloplegia and mydriasis Accommodation spasm (ciliary muscle spasm) 14 Atropine is classified pharmacologically as a: * Direct alpha-adrenergic agonist Muscarinic agonist Nicotinic agonist Non-selective muscarinic antagonist Sympathomimetic agent 15 In the context of cardiac electrophysiology, atropine primarily blocks muscarinic receptors located on which cells? * Atrial muscle cells only SA node and AV node cells Bundle of His cells Purkinje fibers Ventricular myocytes 16 A classic sign of atropine overdose or toxicity is \\\"blind as a bat, mad as a hatter, dry as a bone, red as a beet.\\\" Which symptom corresponds to \\\"dry as a bone\\\"? * Xerostomia (dry mouth) Mydriasis Hyperthermia Urinary retention Blurred vision 17 Which statement accurately describes the effect of atropine on the gastrointestinal tract? * Decreases intestinal peristalsis and tone Enhances absorption of nutrients Stimulates gastric acid secretion Promotes defecation Increases motility and tone 18 The primary mechanism of action for atropine involves: * Inhibition of acetylcholinesterase Blockade of sodium channels in cardiac tissue Irreversible blockade of muscarinic receptors Direct stimulation of nicotinic receptors Competitive and reversible binding to muscarinic receptors 19 Why is atropine sometimes administered in cases of organophosphate poisoning? * To stimulate the nicotinic receptors that have been blocked To directly neutralize the organophosphate agent To enhance the effects of endogenous acetylcholine To act as a competitive inhibitor at nicotinic receptors To block the massive buildup of acetylcholine at muscarinic sites 20 Which of the following statements regarding atropine\\\'s metabolism is correct? * It undergoes extensive first-pass metabolism in the liver. It is conjugated almost exclusively with glucuronic acid. It is largely excreted unchanged in the urine. It is primarily metabolized by CYP3A4 enzymes. It is rapidly hydrolyzed by plasma esterases. ← Previous Next → Submit Quiz ✓