Antiretroviral drugs ✓ Passing Score: 50% 📝 Questions: 11 🎓 Practice Quiz Welcome! This is a practice quiz to test your knowledge. Please enter your details below to participate. Your results will be emailed to you upon completion. Your Information Name * Email * Start Quiz → Question 1 of 11 1 Which of the following antiretroviral agents is a first‑generation NNRTI that is no longer recommended as a preferred option due to high rates of resistance? * Efavirenz Nevirapine Rilpivirine Delavirdine Doravirine 2 Which of the following is NOT a mechanism of action for non‑nucleoside reverse transcriptase inhibitors (NNRTIs)? * Binding to the allosteric pocket of reverse transcriptase Binding to the active site of reverse transcriptase Blocking the incorporation of nucleoside analogues Interfering with the cleavage of the viral polyprotein Inducing a conformational change in reverse transcriptase 3 A patient is prescribed a boosted PI regimen. Which drug is most commonly used as the pharmacokinetic enhancer (boost) in this context? * Saquinavir Ritonavir Nelfinavir Fosamprenavir Indinavir 4 Which of the following antiretroviral medications is known to cause a characteristic orange discoloration of the urine? * Zidovudine Rilpivirine Abacavir Tenofovir disoproxil fumarate Efavirenz 5 A patient on a protease inhibitor (PI) regimens develops a rash and elevated liver enzymes. Which of the following is the most likely PI responsible for these adverse effects? * Atazanavir Indinavir Saquinavir Darunavir Lopinavir/ritonavir 6 Which antiretroviral drug is contraindicated in patients with a history of hypersensitivity to sulfonamides? * Ritonavir Lamivudine Efavirenz Tenofovir disoproxil fumarate (TDF) Raltegravir 7 In the context of HIV treatment, what does the term “cumulative exposure” refer to? * The sum of drug concentrations over time in the bloodstream The total amount of viral load reduction achieved over a year The duration of therapy required to achieve complete immune reconstitution The total number of antiretroviral drugs a patient has ever taken The combined effect of drug toxicity and virologic suppression 8 Which drug class directly inhibits the integration of viral DNA into the host genome? * Entry inhibitors (fusion inhibitors) Integrase strand transfer inhibitors (INSTIs) Protease inhibitors (PIs) Non‑nucleoside reverse transcriptase inhibitors (NNRTIs) Nucleoside reverse transcriptase inhibitors (NRTIs) 9 Which antiretroviral drug is both a nucleoside reverse transcriptase inhibitor (NRTI) and a potent inhibitor of the HIV integrase enzyme when used in combination therapy? * Lamivudine Zidovudine None; NRTIs do not inhibit integrase Emtricitabine Tenofovir alafenamide (TAF) 10 Which of the following statements accurately describes the pharmacologic effect of the drug dolutegravir? * It acts as a prodrug that is metabolized to an active NRTI. It binds to the active site of reverse transcriptase and blocks DNA synthesis. It blocks the fusion of HIV with the host cell membrane. It competitively inhibits the cleavage of the viral Gag polyprotein. It irreversibly binds to the integrase enzyme’s catalytic site. 11 A patient with a low CD4 count and high viral load requires a regimen that can be initiated immediately without waiting for drug susceptibility testing. Which drug class should be used as the backbone? * PIs Entry inhibitors Integrase inhibitors NNRTIs NRTIs ← Previous Next → Submit Quiz ✓
