Broad spectrum antibiotics ✓ Passing Score: 50% 📝 Questions: 10 🎓 Practice Quiz Welcome! This is a practice quiz to test your knowledge. Please enter your details below to participate. Your results will be emailed to you upon completion. Your Information Name * Email * Start Quiz → Question 1 of 10 1 A patient on long‑term tetracycline therapy develops a severe rash that worsens with sun exposure. Which diagnostic test is most appropriate to confirm the reaction? * Phototesting with UVA/UVB exposure Patch testing with tetracycline Skin biopsy for drug‑induced hypersensitivity Serum IgE level measurement Complete blood count with differential 2 Chloramphenicol is contraindicated in which patient population due to a risk of a serious adverse effect? * Individuals with a history of peptic ulcer disease Children under 12 months of age Pregnant women in the first trimester Elderly patients over 70 years old Patients with chronic kidney disease Stage 4 3 When prescribing chloramphenicol for a patient with a history of chronic alcoholism, what precaution should be taken? * Avoid concurrent use of NSAIDs Increase the dose to compensate for metabolic changes Monitor for neutropenia with regular CBCs Ensure adequate folic acid supplementation Check for hepatic enzyme elevations before every dose 4 Which of the following statements about tetracycline resistance is true? * Resistance is mediated by β‑lactamase production. Tetracyclines are never effective against Gram‑positive organisms. Efflux pumps and ribosomal protection proteins are common resistance mechanisms. Resistance is primarily due to bacterial cell wall thickening. Resistance occurs only in anaerobic bacteria. 5 Which of the following bacterial infections is most appropriately treated with a tetracycline class antibiotic? * Acne vulgaris caused by *Propionibacterium acnes* Acute bacterial meningitis caused by *Neisseria meningitidis* Otitis media caused by *Streptococcus pyogenes* Urinary tract infection caused by *Escherichia coli* Community‑acquired pneumonia caused by *Streptococcus pneumoniae* 6 Which of the following is a common adverse effect of tetracyclines that is dose‑dependent? * Nephrotoxicity Ototoxicity Photosensitivity Hepatotoxicity Hemolytic anemia 7 Which of the following patient factors would most likely necessitate a lower dose of a tetracycline? * Concurrent use of a proton‑pump inhibitor Pregnancy in the first trimester Age <12 months Renal insufficiency with a creatinine clearance <30 mL/min Mild hepatic impairment 8 Which of the following is the primary mechanism of action of tetracyclines? * Inhibition of folic acid synthesis by blocking dihydropteroate synthase Inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit Disruption of bacterial DNA replication by inhibiting DNA gyrase Bactericidal activity through generation of reactive oxygen species Inhibition of bacterial cell wall synthesis 9 What is the most significant drug‑drug interaction involving chloramphenicol? * Pharmacokinetic interaction with CYP450 inducers leading to decreased plasma levels Enhanced nephrotoxicity when co‑administered with vancomycin Elevated risk of QT prolongation with macrolides Reduced efficacy when taken with proton‑pump inhibitors Increased risk of bone marrow suppression when combined with aminoglycosides 10 Chloramphenicol exerts its bacteriostatic effect by inhibiting which step in bacterial protein synthesis? * Ribosomal RNA methylation Translocation of the ribosome along mRNA Initiation by blocking the assembly of the 30S subunit Elongation by preventing peptidyl‑tRNA from entering the A site Termination by blocking release factor binding ← Previous Next → Submit Quiz ✓
