aminoglycosides

Pharmacology of Aminoglycoside antibiotics

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Aminoglycosides

INTRODUCTION Aminoglycoside antibiotics are a class of potent, broad-spectrum bactericidal agents that have played a critical role in the management of serious bacterial infections for decades. First derived from microbial sources in the mid-20th century, these compounds quickly became indispensable, especially for treating infections caused by aerobic Gram-negative bacteria. Despite the rise of newer antimicrobial … Read more

Pharmacology of Cephalosporin antibiotics

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cephalosporins antibiotics

Cephalosporin antibiotics are beta-lactam antibiotics derived from Cephalosporium acremonium, classified by generations based on their antimicrobial spectra and pharmacokinetic properties. They are among the most utilized antibiotics globally, due to broad efficacy and good safety profile. I. Mechanism of Action Cephalosporins bind to bacterial penicillin-binding proteins (PBPs) and inhibit the final transpeptidation step of peptidoglycan synthesis in … Read more