Table of ContentsIntroductionHistorical Background and Chemical ClassificationMechanism of ActionBinding to the 50S Ribosomal SubunitBacteriostatic vs. Bactericidal ActivitySpectrum of ActivityPharmacokineticsAbsorptionDistributionMetabolism and EliminationPharmacodynamicsTime-Dependent KillingAUC/MIC ConsiderationsPost-Antibiotic EffectClinical IndicationsNosocomial and Community-Acquired PneumoniaSkin and Soft Tissue Infections (SSTIs)Vancomycin-Resistant Enterococcal InfectionsOther Potential UsesAdverse EffectsHematologic ToxicitiesMitochondrial ToxicitySerotonin SyndromeGastrointestinal and Other EffectsDrug InteractionsSerotonergic Agents and MAO InhibitionPseudoephedrine, PhenylpropanolamineRifampinResistance MechanismsClinical Efficacy: Studies and Comparative … Continue reading Pharmacology of Linezolid