Table of ContentsIntroductionComposition and Rationale of CombinationSulfamethoxazoleTrimethoprimSynergistic RelationshipMechanism of ActionFolic Acid Synthesis InhibitionBactericidal SynergySpectrum of ActivityGram-Positive BacteriaGram-Negative BacteriaOpportunistic OrganismsAtypical or Poor CoveragePharmacokineticsAbsorptionDistributionMetabolismEliminationDosing RegimensTherapeutic IndicationsUrinary Tract Infections (UTIs)Respiratory Tract InfectionsPneumocystis Pneumonia (PCP)Gastrointestinal InfectionsOther IndicationsAdverse EffectsDermatological ReactionsHematological ToxicitiesGastrointestinal DisturbancesHyperkalemiaNephrotoxicityHypersensitivity and Cross-SensitivityContraindications and PrecautionsDrug InteractionsOral Anticoagulants (Warfarin)Oral HypoglycemicsACE Inhibitors / ARBsMethotrexateResistance MechanismsAltered Target EnzymesOverproduction of Target Enzymes / … Continue reading Pharmacology of Co-trimoxazole