Table of ContentsIntroductionPhysiology of FibrinolysisThe Hemostatic and Fibrinolytic BalanceRole of Plasminogen and PlasminRegulation of FibrinolysisClassification of Fibrinolytic Agents1. Tissue Plasminogen Activator (tPA) Derivatives2. Non-Specific Agents3. Other Investigational or Less Commonly Used AgentsMechanisms of ActionGeneral MechanismFibrin-Specific vs. Non-Specific ActivationResistance and InhibitionPharmacokinetics of Key FibrinolyticsAlteplase (Recombinant tPA)ReteplaseTenecteplaseStreptokinaseUrokinaseAnistreplase (APSAC)Clinical Indications1. Acute Myocardial Infarction (ST-Elevation MI)2. Acute Ischemic Stroke3. … Continue reading Pharmacology of Fibrinolytics