Table of ContentsWhat is a “drug”Drug naming and nomenclatureSources and types of drugsPhysicochemical features that matterDrug–target interactionsMajor drug targetsReceptor theory essentialsAgonism beyond “on/off”Spare receptors and couplingGraded vs quantal responsesPharmacokinetics vs pharmacodynamicsMembrane transport and absorptionDistribution: perfusion and bindingCore PK parameters and equationsBioavailability and bioequivalenceRoutes and barriersStereochemistry and specificityProdrugs, metabolites, and “soft” drugsVariability: genes, age, disease, interactionsSafety … Continue reading Nature of the Drugs